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44 — 6 (44) 2022 — Soliev A.U., PATHOGENETIC SIGNIFICANCE OF INSULIN-LIKE GROWTH FACTOR IN THE FORMATION OF CARDIOVASCULAR DISEASES

PATHOGENETIC SIGNIFICANCE OF INSULIN-LIKE GROWTH FACTOR IN THE FORMATION OF CARDIOVASCULAR DISEASES

Soliev A.U., Bukhara State Medical Institute

Resume

In the review article, the author presents studies by foreign scientists devoted to the study of the importance of insulin-like growth factor in the pathogenesis of cardiovascular diseases. All data are systematized and generalized into a single pathogenetic mechanism, direct and indirect neuro-immuno-endocrine effects of the factor on the cardiovascular system are described. Insulin-like growth factors affect growth, metabolism and apoptosis. Most studies have shown a decrease in insulin-like growth factor levels in people with metabolic syndrome or its components and in patients with coronary heart disease. Insulin-like growth factor has anti-inflammatory, antioxidant, hepatoprotective, metabolic (anabolic) effects. Insulin-like growth factor tachycardia, headache and vomiting as a result of transient increase in blood pressure, lipohypertrophy at the injection site, hypertrophy of the tonsils and adenoids, swelling of the face, arthralgia, myalgia, asthenia, orthostatic hypotension and side effects such as hypoglycemia (due to activation of insulin receptors). Insulin-like factor reduces the manifestation of insulin resistance in diabetes, and may contribute to both platelet stabilization and growth in coronary heart disease. In hypertension, it causes vasodilatation, which lowers blood pressure, and stimulates the growth of smooth muscle cells and cardiomyocytes, increases blood pressure

Keywords: Cardiovascular system; insulin-like growth factor; arterial hypertension; diabetes; insulin resistance

First page

231

Last page

239

For citation: Nurimova D.M., Tastanova G.E., INDEPENDENT IN THE STUDY OF ANATOMY THE ROLE OF EDUCATION //New Day in Medicine 6(44)2022 231-239 https://clck.bar/La7202

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