50 — 6 (44) 2022 — Tulemetov S.K., IMMUNOHISTOCHEMICAL EVALUATION OF APOPTOSIS IN THE THYROID AND THYMUS OF OFFSPRING IN A PRENATAL AND EARLY POSTNATAL EXPOSURE TO PESTICIDES

IMMUNOHISTOCHEMICAL EVALUATION OF APOPTOSIS IN THE THYROID AND THYMUS OF OFFSPRING IN A PRENATAL AND EARLY POSTNATAL EXPOSURE TO PESTICIDES

Tulemetov S.K., Tashkent State Dental Institute

Resume

It was revealed that both fipronil and cyhalothrin, when exposed through the mother’s body, cause a pronounced induction of apoptosis in the thyroid and thymus glands of the offspring. Pesticides cyhalothrin and fipronil under conditions of intrauterine and early postnatal exposure induce apoptosis in the thyroid and thymus glands of offspring. In the mechanism of cell apoptosis induction, along with the direct toxic effect of drugs, an important role is played by hypothyroidism and oxidative stress observed in offspring

Keywords: pesticide, apoptosis, fipronil, cyhalothrin, thymus, thyroid

First page

266

Last page

269

For citation: Tulemetov S.K., IMMUNOHISTOCHEMICAL EVALUATION OF APOPTOSIS IN THE THYROID AND THYMUS OF OFFSPRING IN A PRENATAL AND EARLY POSTNATAL EXPOSURE TO PESTICIDES //New Day in Medicine 6(44)2022 266-269 https://clck.bar/L7874f

LIST OF REFERENCES:

1. Goldar S., Khaniani M.S., Derakhshan S.M., Baradaran B. Molecular mechanisms of apoptosis and roles in cancer development and treatment. // Asian Pac J Cancer Prev. – 2015. – Vol. 16(6). – pp. 2129-2144.
2. Ki Y.W., Lee J.E., Park J.H., Shin I.C., Koh H.C.  Reactive oxygen species and mitogen-activated protein kinase induce apoptotic death of SH-SY5Y cells in response to fipronil. // Toxicol Lett. -2012. – Vol. 211(1). – pp. 18-28.
3. Lee J.E., Kang J.S., Ki Y.W., Lee S.H.., et al. Akt/GSK3β signaling is involved in fipronil-induced apoptotic cell death of human neuroblastoma SH-SY5Y cells. //Toxicol Lett. – 2011. – Vol. 202(2). – pp. 133-141.
4. Lin H.Y., Glinsky G.V., Mousa S.A., Davis P.J. Thyroid hormone and anti-apoptosis in tumor cells. //Oncotarget. – 2015. 6(17): – pp. 14735-14743.
5. Muranli F.D. Genotoxic and cytotoxic evaluation of pyrethroid insecticides λ-cyhalothrin and α-cypermethrin on human blood lymphocyte culture. //Bull Environ Contam Toxicol. –  2013. – Vol. 90.(3) – pp. 357-363.
6. Park J.H., Park Y.S., Lee J.B., Park K.H. et al., Meloxicam inhibits fipronil-induced apoptosis via modulation of the oxidative stress and inflammatory response in SH-SY5Y cells. // J Appl Toxicol.  – 2015. Mar 13. doi: 10.1002/jat.3136.
7. Tukhtaev K.R., Tulemetov S.K., Zokirova N.B., Tukhtaev N.K.  Effect of long  term exposure low doses of lambda-cyhalothrin on the level of lipid peroxidation and antioxidant enzymes of the pregnant rats and their offspring. //Medical and Health Science Journal – 2012. – Vol. 13. – pp. 93-98. www.pradec.en
8. Tukhtaev K.R., Tulemetov S.K., Zokirova N.B., Tukhtaev N.K.  et al. Prolonged exposure of low doses of Fipronil causes oxidative stress in    pregnant rats and their offspring. // The Internet Journal of Toxicology.  – 2013. – Vol. 10. –  N. 1. www.ispub.com /IJTO/10/1/14550.
9. Tukhtaev K.R., Zokirova N.B., Tulemetov S.K., Tukhtaev N.K. et al. Effect of Prolonged exposure  low doses of Fipronil on thyroid function of pregnant rats and their offspring. // The Internet Journal of Toxicology.  – 2013. – Vol. 10. –  N. 1. www.ispub.com /IJTO/10/1/14550.
10. Zhang B., Xu Z., Zhang Y., Shao X. et al. Fipronil induces apoptosis through caspase-dependent mitochondrial pathways in Drosophila S2 cells. // Pestic Biochem Physiol. -2015. – Vol.   119.-pp.81-89.