5 — 7 (45) 2022 — Talibnazarova D.D., Rasulov H.A., Xusanov E.S., Abdullaeva I.X., SUBSTANTIATION OF MORPHOLOGY AND METABOLISM OF SPINAL STRUCTURES IN RATS WITH EXPERIMENTAL HYPOTHYROIDISM

SUBSTANTIATION OF MORPHOLOGY AND METABOLISM OF SPINAL STRUCTURES IN RATS WITH EXPERIMENTAL HYPOTHYROIDISM

Talibnazarova D.D., Tashkent Pediatric Medical Institute

Rasulov H.A., Tashkent Pediatric Medical Institute

Xusanov E.S., Tashkent Pediatric Medical Institute

Abdullaeva I.X., Tashkent Pediatric Medical Institute

Resume

The study was conducted on 34 white laboratory rats weighing 150-200 g. In experimental animals, we obtained an experimental model of hypothyroidism by intragastric administration of one of the thyrostatics – mercazolil at a dose of 3 mg/ kg of animal weight.  It was noted that in hypothyroid rats, both the level of markers of bone resorption and the marker of bone formation — bone alkaline phosphatase, reflecting a slowdown in remodeling processes, which ultimately leads to a decrease in bone mass, significantly decreases. The detected morphological changes in the bone-ligamentous structures confirm the negative effect of hypothyroxinemia on the condition of soft tissue structures at the sites of attachment to vertebrae

Key words: bone-ligamentous structures, morphometry, experimental hypothyroidism

First page

23

Last page

26

For citation: Tukhsanova N.E., MORPHOLOGICAL CHANGES OF THE CENTRAL NERVOUS SYSTEM IN ACUTE AND CHRONIC ALCOHOLISM //New Day in Medicine 7(45)2022 23-26 https://l.clck.bar/50ca8

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