11 — 7 (45) 2022 — Khidirova G.O., Yusubjanova S.K., Abdullaeva S.H., Abdullaeva I.X., MORPHOLOGICAL FORMATION OF THE BONE TISSUREIN WHITE RATS WITH HYPOPARATHYROIDISM

MORPHOLOGICAL FORMATION OF THE BONE TISSUREIN WHITE RATS WITH HYPOPARATHYROIDISM

Khidirova G.O., Tashken pediatric medical institute

Yusubjanova S.K., Tashken pediatric medical institute

Abdullaeva S.H., Tashken pediatric medical institute

Abdullaeva I.X., Tashken pediatric medical institute

Resume

The experiments were carried out on 30 mature white rats, which were divided into two groups: control (n=10) and experimental (n= 20). Hypoparathyroid state in experimental animals leads to the development of structural changes in the histology of tubular bones. Signs of destructive and degenerative processes associated with a violation of the state of the intercellular matrix appear in the diaphyses and metaepiphyses of bones, which undoubtedly leads to a decrease in bone strength. It has been established that a decrease in the resorption of differentiated chondrocytes is the most likely cause of the slightly enlarged hypertrophic zone observed in rats.

Key words: bone tissue, bone strength, morphology, hypoparathyroidism.

First page

49

Last page

52

For citation: Khidirova G.O., Yusubjanova S.K., Abdullaeva S.H., Abdullaeva I.X., MORPHOLOGICAL FORMATION OF THE BONE TISSUREIN WHITE RATS WITH HYPOPARATHYROIDISM /New Day in Medicine 7(45)2022 49-52 https://l.clck.bar/798c0

LIST OF REFERENCES:

1. Avtsyn A.P. et al. Human trace elements: etiology, classification, organopathology / A.P. Avtsyn, A.A. Zhavoronkov, M.A. Rish, A.S. Strochkova. – M.: Medicine, 1991.- 496 p.
2. Kazimirko V.K. et al. Osteoporosis: pathogenesis, clinic, prevention and treatment / V.K. Kazimirko, V.A. Kovalenko, V.I.Maltsev. – Kiev: Marion, 2006. – 160 p.
3. Mikhailichenko V.Yu. et al. Pathophysiological aspects of hypothyroidism in rats in an experiment / V.Yu. Mikhailichenko, V.A. Konoplyanko, O.V. Vasilyanskaya [et al.] // Bulletin of emergency and restorative medicine. – 2012. – Vol. 13, No. 1. – pp. 86-89.
4. Rasulov H.A. The influence of thyroid hypofunction on the formation of congenital orthopedic pathology in children / Sb. tez. Human Sciences V Congress of Young Scientists and Specialists., – Tomsk, 2004. – pp. 178-179.
5. Peppa M, Koliaki C, Nikolopoulos P, Raptis S.A. Skeletal muscle insulin resistance in endocrine disease. // J.Biomed. Biotechnol. 2010; 2010. 527850.
6. Javed Z., Sathyapalan T. Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits. Ther. Adv. Endocrinol. Metab. 2016; 7: 12–23.