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  • 56 -7 (45) 2022 — A.G. Bozorov, G.A. Ikhtiyarova — PREDICTING THERISK OF PRETERM BIRTH IN CASES OF GENITOURINARY SYSTEM INFECTION

56 -7 (45) 2022 — A.G. Bozorov, G.A. Ikhtiyarova — PREDICTING THERISK OF PRETERM BIRTH IN CASES OF GENITOURINARY SYSTEM INFECTION

PREDICTING THERISK OF PRETERM BIRTH IN CASES OF GENITOURINARY SYSTEM INFECTION

A.G. Bozorov, Bukhara State Medical Institute, Uzbekistan

G.A. Ikhtiyarova Bukhara State Medical Institute, Uzbekistan

Resume

Preterm birth are associated with a high incidence of neonatal and perinatal morbidity and mortality, and therefore are amongthe most pressing problems of obstetrics. Taking into account the urgency of the problem, we conducted a study of biochemical markers: metalloproteinase-12 and cystatin C in pregnant women at risk of preterm labor and the presence of an infection of the genitourinary system.

The aim of the study is to predict the threat of preterm labor against the background of urogenital tract infection, taking into account the study of biochemical markers.

Material and methods. To solve the tasks set in the work, 128 women (Group I-65 women with IMS and at risk preterm birth and II 63 women with preterm birth (group without infections) and 25 women in the control group are conditionally healthy pregnant women who will undergo an enzyme-linked immunosorbent assay (ELISA). The level of metalloproteinase 12, cystatin C in the blood serum.

Research results. There was an association of high plasma levels of matrix metalloproteinase-12 (ADAM-12) in pregnant women with BMI (9.1-11 ng/ml in 49.2% of women) compared to pregnant women with risk of miscarriage without BMI (7.1-9.0 ng/ml in 7.9% of women) and the control group (3.1-5.0,0 ng/ml in 16% of women). The level of cystatin C in the blood serum is inversely proportional to the glomerular filtration rate.   The worse the kidneys filter (renal failure), the higher the concentration of cystatin C. The assay is used to evaluate renal function as an alternative to creatinine testing.

Key words: preterm labor, urogenital system infection, metalloproteinase-12, cystatin C

First page

294

Last page

300

For citation: A.G. Bozorov, G.A. Ikhtiyarova PREDICTING THERISK OF PRETERM BIRTH IN CASES OF GENITOURINARY SYSTEM INFECTION //New Day in Medicine 7(45)2022 294-300 https://clck.ru/sLVCp

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