57 -7 (45) 2022 — Dustova N.K. — PATHOMORPHOLOGY OF THE PLACENTA IN SARS-CoV-2 CORONAVIRUS INFECTION

PATHOMORPHOLOGY OF THE PLACENTA IN SARS-CoV-2 CORONAVIRUS INFECTION

Dustova N.K. Bukhara State Medical Institute named after Abu Ali ibn Sino, Uzbekistan

Resume

Information about pathomorphological changes in the placenta during infection caused by SARS-CoV-2 is currently scarce, largely contradictory and mainly concerns literature reviews. Data are particularly lacking on changes in the placenta in COVID-19 depending on gestational age, disease severity, pregnancy complications, and their impact on perinatal outcomes. There is evidence that the SARS-CoV-2 virus enters the placenta not only by ascending, hematogenous, but also sexually and causes morphological changes in many reproductive organs, including the placenta. Due to the tropism of the virus to cells expressing angiotensin-converting enzyme-2 (ACE2), it is necessary to purposefully analyze stromal-vascular and immuno-inflammatory changes in the umbilical cord, fetal membranes, villi, decidual and chorionic plates. From the bulk material of the central pathomorphological laboratory of the Ministry of Defense of the Russian Federation, placentas of women who recovered from COVID-19 in 2021 were selected. The analysis of clinical data, clinical-morphological and immunohistochemical study of 33 placentas was carried out in order to identify violations of morphogenesis under the influence of the SARS-CoV-2 virus and to search for target receptors in all structural formations of the placenta. It was found that in the placentas of women who had a new coronavirus infection in the 2nd and 3rd trimesters of pregnancy, signs of malperfusion and immunoinflammatory changes were found much more often than in the 1st trimester. The frequency of intrauterine infection detected in placentas also increased compared to the results of the study of placentas in 2013 (historical control). According to the authors, a comprehensive study of placentas, women who have had an infection of varying severity and at different stages of pregnancy will help clarify the pathogenesis of COVID-19 and develop methods for preventing pregnancy complications in a pandemic of a new coronovirus infection.

Key words: COVID-19, SARS-CoV-2, intrauterine infection, placenta, malperfusion.

First page

301

Last page

310

For citation: Dustova N.K. PATHOMORPHOLOGY OF THE PLACENTA IN SARS-CoV-2 CORONAVIRUS INFECTION //New Day in Medicine 7(45)2022 301-310 https://clck.ru/sLVDs

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