62 -7 (45) 2022 — Akhmedov F.K., Inoyatov A.Sh. — THE ROLE OF MATERNAL SERUM INTERLEUKIN 1-Β(IL-1Β) IN PREECLAMPSIA: DIAGNOSIS AND PROGNOSIS
THE ROLE OF MATERNAL SERUM INTERLEUKIN 1-Β(IL-1Β) IN PREECLAMPSIA: DIAGNOSIS AND PROGNOSIS
Akhmedov F.K., Bukhara State Medical Institute, Uzbekistan
Inoyatov A.Sh. Bukhara State Medical Institute, Uzbekistan
Resume
Hypertensive disorders during pregnancy are associated with high maternal and perinatal mortality, so it is very important for obstetricians to recognize severe cases with a poor prognosis in time. One of the pathogenesis of preeclampsia is an increase in the level of IL-1β. In preeclampsia, in contrast to normal pregnancy, the cytokine profile changes – higher concentrations of IL-1β are noted. Although the final pathogenesis of this pathology remains to be elucidated, on the basis of this it will be possible to develop an adequate therapy algorithm to save the life of the mother and child.
Key words: preeclampsia, interleukin, IL-1β pregnancy, immunology.
First page
329
Last page
333
For citation: Akhmedov F.K., Inoyatov A.Sh. THE ROLE OF MATERNAL SERUM INTERLEUKIN 1-Β(IL-1Β) IN PREECLAMPSIA: DIAGNOSIS AND PROGNOSIS //New Day in Medicine 7(45)2022 329-333 https://clck.ru/sNtzG
LIST OF REFERENCRS:
- Ахмедов Ф.К., Курбонова З.Ш. Мочевая кислота – маркер развития преэклампсия // Новости дерматологии и репродуктивного здоровья. – 2017. – №3-4(II). – С. 27-29.
- Akhmedov F.K., Negmatullaeva M.N., Features of the state of central hemodynamics and hemostasis in pregnant women with preeclampsia of varying severity //New Day in Medicine 1(29)2020 144-147 https://newdaymedicine.com/?p=5599
- Tuksanova D.I., Avakov V.E., Nazhmutdinova D.K. Features of the state of the parameters of homeostasis and cardio hemodynamics in women with physiological pregnancy //New Day in Medicine 1(25)2019 159-162 https://cutt.ly/LbFgwrT
- Туксанова Д.И. Особенности изменений показателей системного и органного кровотока у женщин при тяжёлой преэклампсией // Международный Казахско-Турецкий Университет “Современная медицина традиции и инновации”. – Казакстан 2018. – С. 151-155.
- Кашкин, К. П. Цитокины иммунной системы: основные свойства и иммунобиологическая активность / К. П. Кашкин // Клинич. лаб. диагностика. – 2018. – № 11. – С. 21-32.
- Akhmedov F.K. Peculiarities of cardiac hemodynamic in pregnant women with mild preeclampsia // Europen Science Review. – Austria, Vienna, 2015, № 4-5 – С. 56–58.
- Bargetzi M.J. Interleukin-1 beta induces unterleukin-1 receptor antagonist and tumor necrosis factor binding protein in humans / M. J. Bargetzi, M. Lantz, C. G. Smith [et al.] // Cancer. Res. – 2017. – Vol. 53, № 17. – Р. 4010-4013.
- Girard S. IL-1 receptor antagonist protects against placental and neurodevelopmental detects induced by maternal inflammation / S. Girard, L. Tremblay, M. Lepage [et al.] // J. Immunol. – 2015. – Vol. 184, № 7. – Р. 3997-4005.
- Granowitz E.V. Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: IL-1 receptor antagonist inhibits lipopolysackharide-induced cytokine synthesis by human monocytes / E.V. Granowitz, E. Vannier, D.D. Poutsiaka [et al.] // Blood. – 2017. – Vol. 79, № 9. – Р. 2364-2369.
- Huang H.Y. Interleukin (IL)-1β regulation of IL-1β and IL-1 receptor antagonist expression in cultured human endometrial stromal cells / H. Y. Huang, Y. Wen, J. S. Kruessel [et al.] // J. Clin. Endocrinol. Metab. – 2011. – Vol. 86, № 3. – Р. 1387-1393.
- Maedler K. et al. Leptin modulates β-cell expression of IL-1 receptor antagonist and release of IL-1β in human islets / K. Maedler, J. Oberholzer, P. Bucher [et al.] // PNAS. – 2014. – Vol. 101, № 21. – Р. 8138-8143.
- Mulla M.J. Uric acid induces trophoblast IL-1β production via the inflammasome: implications for the pathogenesis of preeclampsia / M.J. Mulla, K. Myrtolli, J. Potter [et al.] // Am. J. Reprod. Immunol. – 2011. – Vol. 61, № 6. – Р. 542- 548.
- Laresgoiti-Servitje E. A leading role for the immune system in the pathophysiology of preeclampsia. J Leukoc Biol. 94:247–257. 2013.