7 -8 (46) 2022 — Irgasheva S.U. Sadirova S.S. — OVARIAN FUNCTION IN DIFFERENT PHENOTYPES OF POLYCYSTIC OVARY SYNDROME IN WOMEN OF REPRODUCTIVE AGE
OVARIAN FUNCTION IN DIFFERENT PHENOTYPES OF POLYCYSTIC OVARY SYNDROME IN WOMEN OF REPRODUCTIVE AGE
Irgasheva S.U. Republican Specialized Scientific and Practical Center for Obstetrics and Gynecology.Tashkent. Uzbekistan.
Sadirova S.S. Republican Specialized Scientific and Practical Center for Obstetrics and Gynecology.Tashkent. Uzbekistan.
Resume
This article analyzes the assessment of the functional state of the ovaries in women with various PCOS phenotypes by examining the hormones of the pituitary-ovarian system and evaluating the results of the functional test with letrozole. The results of the study indicate the existing differences in hormonal features and activity of the enzyme cytochrome p-450 ovarian aromatase in women with polycystic ovary syndrome of reproductive age.
Key words: PCOS, phenotypes, women of reproductive age, hormones, cytochrome P-450, aromatase.
First page
39
Last page
43
For citation: Irgasheva S.U. Sadirova S.S. OVARIAN FUNCTION IN DIFFERENT PHENOTYPES OF POLYCYSTIC OVARY SYNDROME IN WOMEN OF REPRODUCTIVE AGE //New Day in Meidicine 8(46)2022 44-50 https://clck.ru/sQ5Ms
LIST OF REFERENCES:
- Irgasheva S.U., Gulammahmudova D.V., D.V. Alieva M.M. Comparative evaluation of clinical indicators of various forms of polycystic ovaries. // News dermatovenereology and reproductive health, 2017, No. 4, p.59-60
- Irgasheva S.U., Alieva M.M., Kurbanova D.A., Mirzaeva Yu.K. The state of the ovarian reserve in women with polycystic ovary syndrome. // News of dermatovenereology and reproductive health, 2020, no. 1-2, p. 37-39.
- Timofeeva E.T., Misharina E.V., Nikolaenkov I.P., Samoilovich Ya.A., Tkachenko N.N.. Methodical approaches to the determination of ovarian aromatase in polycystic ovary syndrome. // Obstetrics and women’s diseases. 2016 No. 1 P. 54-61.
- The Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) // Hum. Reprod. 2004. Vol. 19, N 1. P. 41–47..
- Николаенков И.П., Потин В.В., Тарасова М.А., Ярмолинская М.И., Ткаченко Н.Н., Самойлович Я.А., Тимофеева Е.М. Активность овариальной ароматазы у больних синдромом поликистозных яичников. // Журнал акушерства и женскихь бользней. 2014 № 1. С.10-15.
- Erickson G. Follicle growth and development. // Gynecol Obstet. 2001;5(12):2061-2071.
- Merlotti D, Gennari L, Stolakis K, et al. Aromatase activity and bone loss n men. // J Osteoporos. 2011:1- 11. : 10.4061/2011/230671.
- Matsumine H., Hirato K., Yanaihara T. et al. Aromatization by skeletal muscle. // J Clin Endocrinol Metab. 1986; 63(3):717-720. : 10.1210/jcem‑63-3-717.
- Ackerman G.E., Smith E., endelson C.R., et al. Aromatization f androstenedione by human adipose tissue stromal cells n monolayer culture. // J Clin Endocnnol Metab. 1981; 53:412-417. : 10.1210/jcem‑53-2-412.
- Santen R.J., Brodie H., Simpson E.R., et al. History f aromatase: saga f an mportant biological mediator and therapeutic target. // Endocr Rev. 2009; 30(4):343-375. doi: 10.1210/er.2008-0016.