61 — 8 (46) 2022 — Yuldasheva S.Z., Shurygina O.V., METHODS FOR THE ASSESSMENT OF HUMAN EMBRYOS TO INCREASE REPRODUCTIVE CAPACITY

METHODS FOR THE ASSESSMENT OF HUMAN EMBRYOS TO INCREASE REPRODUCTIVE CAPACITY

Yuldasheva S.Z., Tashkent Pediatric Medical Institute

Shurygina O.V., Samara State Medical University

Resume

In some clinics, advanced technology of continuous video surveillance of embryo development has been introduced, the system is based on the use of innovative time-lapse technology, during which each embryo is photographed with a given frequency from the moment of fertilization and throughout the incubation period [7,8,9]. The aim of the study. Optimization of the in vitro fertilization program with a differentiated approach to the use of time-lapse technology or video surveillance of embryo development. In the study groups with video surveillance, higher hCG(+)/CNB results were obtained and the difference between these indicators is minimal, which indicates the high quality of embryos that are selected for transfer (IVF 36.7±6%/34.3±7.1% using video surveillance and 42.5±7.4%/36±6.7% without video surveillance; ICSI 30.1±6.6%/24.1±5% using video surveillance and 35±6.6%/25.3±4.9% without video surveillance). In the group of older reproductive age (36+ years), time lapse technology demonstrates even higher significance. The difference between the indicators of hCG(+) / CNB 34.7±8.1% / 30.5±4.6% is minimal in the group with video surveillance. 36The analysis of morphokinetic parameters of preimplantation embryo development allows selecting competent embryos for transfer to the uterine cavity and cryopreservation.

Keywords: assisted reproductive technologies, infertility, elective blastocyst transfer, time-lapse microscopy, morphokinetics.

First page

365

Last page

373

For citation: Yuldasheva S.Z., Shurygina O.V., METHODS FOR THE ASSESSMENT OF HUMAN EMBRYOS TO INCREASE REPRODUCTIVE CAPACITY //New Day in Medicine 8(46)2022 365-373 https://l.clck.bar/b86e7

LIST OF REFERENCES:

1. Иванова О.В., Шурыгина О.В., Русаков Д.Ю. Быкова Т.В., Петрова А.А., Юхимец С.Н., Кулакова О.В., Юлдашева С.З. Оценка эффективности криоконсервация гамет и эмбрионов человека в программах вспомогательных репродуктивных технологий // Морфологические ведомости. – 2019.- Том 27.- № 3.- С. 46-50. https://doi.org/10.20340/mv-mn.19(27).03.46-50
2. Coticchio G., Mignini Renzini M., Novara P.V., Lain M., De Ponti E., Turchi D., Fadini R., Dal C.M. Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability. // Hum Reprod 2018;33:23–31.
3. Reignier A., Lammers J., Barriere P., Freour T. Can time-lapse parameters predict embryo ploidy? A systematic review. // Reprod Biomed Online 2018;36:380–387.
4. Zaninovic N., Irani M., Meseguer M. Assessment of embryo morphology and developmental dynamics by time-lapse microscopy: is there a relation to implantation and ploidy? // Fertil Steril 2017; 108:722–729.
5. Rocafort E., Enciso M., Leza A., Sarasa J., Aizpurua J. Euploid embryos selected by an automated time-lapse system have superior SET outcomes than selected solely by conventional morphology assessment. // J Assist Reprod Genet 2018;
6. De los Santos M.J., Apter S., Coticchio G., Debrock S., Lundin K., Plancha C.E., Prados F., Rienzi L., Verheyen G. Woodward B et al. revised guidelines for good practice in IVF laboratories (2015). // Hum Reprod 2016;31:685–686.
7. Brison D.R., Roberts S.A., Kimber S.J. How should we assess the safety of IVF technologies? // Reprod Biomed Online 2013;27:710–721.
8. Harper J., Jackson E., Sermon K., Aitken R.J., Harbottle S., Mocanu E., Hardarson T., Mathur R., Viville S., Vail A. et al. . Adjuncts in the IVF laboratory: where is the evidence for ‘add-on’ interventions? // Hum Reprod 2017;32:485–491.
9. Armstrong S., Bhide P., Jordan V., Pacey A., Marjoribanks J., Farquhar C. Time-lapse systems for embryo incubation and assessment in assisted reproduction. // Cochrane Database Syst Rev 2019;Cd011320.
10. Polanski L.T., Coelho Neto M.A., Nastri C.O., Navarro P.A., Ferriani R.A., Raine-Fenning N., Martins W.P. Time-lapse embryo imaging for improving reproductive outcomes: systematic review and meta-analysis. // Ultrasound Obstet Gynecol 2014;44:394–401.
11. Chen M., Wei S., Hu J., Yuan J., Liu F. Does time-lapse imaging have favorable results for embryo incubation and selection compared with conventional methods in clinical in vitro fertilization? A meta-analysis and systematic review of randomized controlled trials. // PLoS One 2017;12:e0178720.