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  • 103 — 8 (46) 2022 — Ibadova M.U., Saidov S.A., Tulaboeva G.M., Kayumov U.K., IEVALUATION OF CORTISOL, GLYCEMIA, C-PEPTIDE AND BODY WEIGHT PARAMETERS IN MODELING OF METABOLIC SYNDROME IN RABBITS

103 — 8 (46) 2022 — Ibadova M.U., Saidov S.A., Tulaboeva G.M., Kayumov U.K., IEVALUATION OF CORTISOL, GLYCEMIA, C-PEPTIDE AND BODY WEIGHT PARAMETERS IN MODELING OF METABOLIC SYNDROME IN RABBITS

IEVALUATION OF CORTISOL, GLYCEMIA, C-PEPTIDE AND BODY WEIGHT PARAMETERS IN MODELING OF METABOLIC SYNDROME IN RABBITS

Ibadova M.U., European Medical University

Saidov S.A., Tashkent Pharmaceutical Institute

Tulaboeva G.M., Center for the Development of Professional Qualifications of Medical Workers

Kayumov U.K., Center for the Development of Professional Qualifications of Medical Workers

Resume

The state of cortisol, glycemia, C-peptide, and body weight levels in rabbits with experimental metabolic syndrome was studied. The study was conducted on 16 mongrel rabbits weighing from 2000 to 2700 grams. The experiment lasted 60 days, during which the rabbits were in a state of inactivity. To simulate the metabolic syndrome, cholesterol, sucrose, and insulin were added to the rabbits’ food. As a result of the study, it was found that in the experimental group (10 rabbits), there was a significant increase in the level of the components under consideration. It has been shown that during the simulation of the metabolic syndrome, along with the generally accepted signs of insulin resistance, cortisol levels also significantly increase. At the same time, cortisol levels had certain connections with other components of the metabolic syndrome. In the control group (6 rabbits), the dynamics of the levels of the studied indicators were insignificant and statistically insignificant. The data obtained suggest a pathogenetic relationship between hypercortisolemia and metabolic syndrome.

Keywords: metabolic syndrome, insulin resistance, cortisol, glucose, body weight, C-peptide, experiment, modeling.

First page

633

Last page

637

For citation: Ibadova M.U., Saidov S.A., Tulaboeva G.M., Kayumov U.K., IEVALUATION OF CORTISOL, GLYCEMIA, C-PEPTIDE AND BODY WEIGHT PARAMETERS IN MODELING OF METABOLIC SYNDROME IN RABBITS //New Day in Medicine 8(46)2022 https://l.clck.bar/89815

LIST OF REFERENCES:

  1. CDC. National Diabetes Statistics Report, 2020
  2. Kayumov U.K., Kalandarova U.A., Ibragimov A.Yu., Saipova M.L. The prevalence of ischemic heart disease and mortality from this disease at various components of metabolic syndrome//New Day in Medicine 3(27)2019 138-141 Ukl https://cutt.ly/EbxUwLm
  3. Khidoyatova M.R., Kayumov U.K., Inoyatova et al. Clinical status of patients with coronary artery disease post COVID-19. // International Journal of Health & Medical Sciences, 2022, 5(1), 137-144. https://doi.org/10.21744/ijhms.v5n1.1858
  4. Bourebaba Y. et al. Catestatin peptide of chromogranin A as a potential new target for several risk factors management in the course of metabolic syndrome // Biomedicine & Pharmacotherapy, Volume 134, 2021, 111113. https://doi.org/10.1016/j.biopha.2020.111113
  5. Черныш П.П., Каюмов У.К., Хайдарова Ф.А., Максутова Н.Н. Генез инсулинорезистентности при сахарном диабете 2 типа: наследственно обусловленный или кортизолзависимый? // Украинский терапевтический журнал, 2014, №2, С. 65-69.
  6. Boyle S.H., Surwit R.S., Georgiades A. et al. Depressive symptoms, race, and glucose concentrations: the role of cortisol as mediator. // Diabetes Care. 2007 Oct; 30(10):2484-8. doi: 10.2337/dc07-0258. Epub 2007 Jul 13. PMID: 17630268.
  7. Schulte A.E., Olckers A. Metabolic syndrome // Horm. Metab. Res. 2011, №9, P. 651-657.
  8. Каримов Х.Я., Мухаммедов Х.А., Юлдашев Н.М., Саидов С.А. Способ моделирования метаболического синдрома у кроликов. / Патент Республики Узбекистан IAP 20050314 от 15 ноября 2005г.

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