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  • 1 — 9 (47) 2022 — Teshaev Sh.J., Temirov O.O., Khakimov Y.SH., STUDY OF MORPHOLOGICAL AND MORPHOMETRIC PARAMETERS OF THE ESOPHAGE OF WHITE RATS AGED FROM 3 TO 6 MONTHS UNDER THE INFLUENCE OF 4 DIFFERENT ANTI-INFLAMMATORY DRUGS UNDER THE CONDITIONS OF POLYPROGMASIA

1 — 9 (47) 2022 — Teshaev Sh.J., Temirov O.O., Khakimov Y.SH., STUDY OF MORPHOLOGICAL AND MORPHOMETRIC PARAMETERS OF THE ESOPHAGE OF WHITE RATS AGED FROM 3 TO 6 MONTHS UNDER THE INFLUENCE OF 4 DIFFERENT ANTI-INFLAMMATORY DRUGS UNDER THE CONDITIONS OF POLYPROGMASIA

STUDY OF MORPHOLOGICAL AND MORPHOMETRIC PARAMETERS OF THE ESOPHAGE OF WHITE RATS AGED FROM 3 TO 6 MONTHS UNDER THE INFLUENCE OF 4 DIFFERENT ANTI-INFLAMMATORY DRUGS UNDER THE CONDITIONS OF POLYPROGMASIA

Teshaev Sh.J., Bukhara State Medical Institute

Temirov O.O., Bukhara State Medical Institute

Khakimov Y.SH. Bukhara State Medical Institute

Resume

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most effective and widely used agents for the pathogenetic treatment of acute or chronic pain. However, NSAIDs have a specific negative effect on the gastrointestinal tract. In recent years, the number of works devoted to lesions of the esophagus while taking NSAIDs has increased. In this work, the morphological and morphometric parameters of the esophagus of 50 white rodents aged from 3 to 6 months were studied and analyzed under the influence of 4 different anti-inflammatory drugs on polypragma.

Keywords: esophagus, polypragmasia, morphology, morphometry, anti-inflammatory agents.

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For citation: Teshaev Sh.J., Temirov O.O., Khakimov Y.SH., STUDY OF MORPHOLOGICAL AND MORPHOMETRIC PARAMETERS OF THE ESOPHAGE OF WHITE RATS AGED FROM 3 TO 6 MONTHS UNDER THE INFLUENCE OF 4 DIFFERENT ANTI-INFLAMMATORY DRUGS UNDER THE CONDITIONS OF POLYPROGMASIA //New Day in Medicine 9 (47)2022 2-6 https://l.clck.bar/40b21

LIST OF REFERENCES:

  1. Golovanova E.V. Protection of the gastrointestinal mucosa from the damaging effects of non-steroidal anti-inflammatory drugs // Clinical Gerontology. – 2017. – No. 1-2. – P.47-51.
  2. Dikareva E.A., Pimanov S.I., Makarenko E.V. Assessment of the risk of developing gastropathy induced by the use of non-steroidal anti-inflammatory drugs, based on international consensus documents. // Bulletin of the Voronezh State Medical University. – 2015. – No. 5. – P.39-45.
  3. Dubikov A.I. Non-steroidal anti-inflammatory drugs: once again about the main thing // Clinical gerontology. -.2009. – No. 7-13.
  4. Efimov A.L., Sigua B.V., Filaretova L.P. Acute ulcers and erosions of the gastrointestinal tract induced by non-steroidal anti-inflammatory drugs: etiology, pathogenesis, treatment tactics // Bulletin of the Russian Military Medical Academy. – 2017. – No. 1 (57). – S. 198-204.
  5. Karateev A.E., Uspensky Yu.P., Pakhomova I.G. NSAID use and esophageal pathology: relationship with the main symptoms of gastroesophageal reflux disease, incidence and risk factors for erosive esophagitis // Experimental and Clinical Gastroenterology. 2008. No. 3. S. 6–11.
  6. Karateev A.E., Yakhno N.N., Lazebnik L.B. and other Use of non-steroidal anti-inflammatory drugs. Clinical guidelines. Moscow: IMA-press, 2009.
  7. Karkishchenko V.N., Karkishchenko N.N., Shustov E.B. Pharmacological bases of therapy // Guide for doctors and students. Moscow, St. Petersburg 2018
  8. Karateev A.E., Nasonov E.L., Yakhno N.N., Ivashkin V.T., Chichasova N.V., Alekseeva L.I. and others. Rational use of non-steroidal anti-inflammatory drugs (NSAIDs) in clinical practice // Clinical recommendations. Modern rheumatology. No. 1. 2015. P.4-18
  9. Karateev A.E., Yakhno N.N., Lazebnik L.B. and other Use of non-steroidal anti-inflammatory drugs. Clinical guidelines. Moscow: IMA-press, 2009.
  10. Pakhomova I.G., Belousova L.N. Lesions of the upper gastrointestinal tract associated with the use of non-steroidal anti-inflammatory drugs // Effective pharmacotherapy. – 2014. – No. 49. – S. 24-31.
  11. Pakhomova I.G., Uspensky Yu.P., Edemskaya M.A. Lesions of the esophagus in patients with osteoarthritis taking non-steroidal anti-inflammatory drugs // Practical Medicine. 2012. No. 3. S. 86–90.
  12. Pinchuk T.P., Abakumov M.N., Luzhnikov E.A. Esophagoimpedansometry for chemical burns of the esophagus // Toxicological Bulletin. 2005. No. 3. S. 2–6.
  13. Hawkey C.J., Lain L., Harper S.E. et al. Influence of risk factors on endoscopic and clinical ulcers in patients taking rofecoxib or ibuprofen in two randomized controlled trials // Aliment. Pharmacol. Ther. 2001. Vol. 15. № 10. P. 1593–1601.
  14. Ruszniewski P., Soufflet C., Barthélémy P. Nonsteroidal anti-inflammatory drug use as a risk factor for gastrooesophageal reflux disease: an observational study // Aliment. Pharmacol. Ther. 2008. Vol. 28. № 9. P. 1134–1139.
  15. Taha A., Angerson W., Morran C. Correlation between erosive oesophagealand gastro-duodenal diseases. The influence of aspirin, simple analgesics, and Helicobacter pylori // Eur. J. Gastroenterol. Hepatol. 2002. Vol. 14. № 12. P. 1313–1317.
  16. Venerino M., Malfertheiner P. Interaction of Helicobacter pylori infection and nonsteroidal anti-inflammatory

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