86 — 9 (47) 2022 — Umarov D.A., STUDYING THE VOLUME AND INTENSITY OF BLOOD LOSS FROM THE SKIN WOUND ON THE BACKGROUND OF THE EXPERIMENTAL MODEL OF DRUG HYPOCOAGULATION

STUDYING THE VOLUME AND INTENSITY OF BLOOD LOSS FROM THE SKIN WOUND ON THE BACKGROUND OF THE EXPERIMENTAL MODEL OF DRUG HYPOCOAGULATION

Umarov D.A., Urgench branch of the Tashkent Medical Academy

Resume

The authors of the article set themselves the goal of evaluating the effectiveness of the «Hemoben» application hemostatic agent in an experimental model of a skin wound against the background of drug-induced hypocoagulation and studying the features of local hemostasis using «Hemoben» gel on a model of anal sphincter dissection in rats.

The subject of the study were 72 male white rats that were experimented in the Department of Experimental Surgery of the Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov for 2020-2021 In animals on the background of drug hypocoagulation in the control group, electrocoagulation of bleeding areas was performed for the purpose of hemostasis from the site of the dissected anal sphincter. Subsequently, an ointment turunda is left. In the experimental group of animals, hemostasis was achieved by leaving gauze turunda impregnated with «Hemoben» hemostatic gel. The application of the hemostatic agent «Hemoben» on the skin wound of experimental animals under the conditions of the drug hypocoagulation model helped to reduce the period for achieving final hemostasis and eliminates the risk of recurrent bleeding.

Key words: experimental study, animal anus wound, drug hypocoagulation, «Hemoben»

First page

508

Last page

513

For citation: Umarov D.A., STUDYING THE VOLUME AND INTENSITY OF BLOOD LOSS FROM THE SKIN WOUND ON THE BACKGROUND OF THE EXPERIMENTAL MODEL OF DRUG HYPOCOAGULATION //New Day in Medicine 9 (47)2022 508-513 https://l.clck.bar/b27d6

LIST OF REFERENCES:

1. Sun Z., Migaly J. Review of Hemorrhoid Disease: Presentation and Management. Clin Colon Rectal Surg. 2016;29(1):22-9.
2. Pata F., Sgró A., Ferrara F., Vigorita V., Gallo G., Pellino G. Anatomy, Physiology and Pathophysiology of Haemorrhoids. Rev Recent Clin Trials. 2021;16(1):75-80.
3. Tournu G., Abramowitz L., Couffignal C., Juguet F., Sénéjoux A. et al.; GREP study group; MG-PREVAPROCT study group. Correction to: Prevalence of anal symptoms in general practice: a prospective study. // BMC Fam Pract. 2019;20(1):14.
4. Salusso P., Testa V., Mochet S., Arezzo A., Allaix M.E., Salzano A., Morino M., Mistrangelo M. Management of Hemorrhoidal Disease in Special Conditions: A Word of Caution. Rev Recent Clin Trials. 2021; 16(1):22-31.
5. Aigner F., Gruber H., Conrad F., Eder J., Wedel T., Zelger B., Engelhardt V., Lametschwandtner A., Wienert V., Böhler U., Margreiter R., Fritsch H. Revised morphology and hemodynamics of the anorectal vascular plexus: impact on the course of hemorrhoidal disease. // Int J Colorectal Dis. 2009 Jan;24(1):105-13. doi: 10.1007/s00384-008-0572-3.
6. Pata F., Sgró A., Ferrara F., Vigorita V., Gallo G., Pellino G. Anatomy, Physiology and Pathophysiology of Haemorrhoids. Rev Recent Clin Trials. 2021; 16(1):75-80. doi: 10.2174/1574887115666200406115150.
7. Margetis N. Pathophysiology of internal hemorrhoids. Ann Gastroenterol. 2019 May-Jun; 32(3):264-272. doi: 10.20524/aog.2019.0355. Epub 2019 Jan 23. PMID: 31040623; PMCID: PMC6479658.
8. Zagriadskiǐ E.A, Bogomazov A.M, Golovko EB. Conservative Treatment of Hemorrhoids: Results of an Observational Multicenter Study. Adv Ther. 2018;35(11):1979-92.
9. Lin H.C., He Q.L., Shao W.J., Chen X.L., Peng H., Xie S.K., Wang X.X., Ren D.L. Partial Stapled Hemorrhoidopexy Versus Circumferential Stapled Hemorrhoidopexy for Grade III to IV Prolapsing Hemorrhoids: A Randomized, Noninferiority Trial. Dis Colon Rectum. 2019 Feb; 62(2):223-233. doi:10.1097/DCR.0000000000001261.
10. Hollingshead J.R., Phillips R.K. Haemorrhoids: modern diagnosis and treatment. // Postgrad Med J. 2016;92(1083):4-8. doi: 10.1136/postgradmedj-2015-133328.