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  • 87 — 9 (47) 2022 — Ismailov O.S., Batirov D.Yu., Rakhimov A.P., Azadov B.R., Yusupov D.D., MOLECULAR GENETIC INTERRELATION OF GALLSTONE DISEASE AND METABOLIC SYNDROME

87 — 9 (47) 2022 — Ismailov O.S., Batirov D.Yu., Rakhimov A.P., Azadov B.R., Yusupov D.D., MOLECULAR GENETIC INTERRELATION OF GALLSTONE DISEASE AND METABOLIC SYNDROME

MOLECULAR GENETIC INTERRELATION OF GALLSTONE DISEASE AND METABOLIC SYNDROME

Ismailov O.S., Ministry of Health of the Republic of Uzbekistan. Office of science and educational institutions.

Batirov D.Yu., Urgench branch of the Tashkent Medical Academy

Rakhimov A.P., Urgench branch of the Tashkent Medical Academy

Azadov B.R., Urgench branch of the Tashkent Medical Academy

Yusupov D.D., Urgench branch of the Tashkent Medical Academy

Resume

This research work was carried out on the basis of the Department of Faculty and Hospital Surgery of the Urgench branch of the Tashkent Medical Academy in the surgical departments of the Khorezm Regional Diversified Medical Center based on clinical analysis and diagnostic results of patients with cholelithiasis with MS and cholelithiasis without metabolic disorders. Molecular genetic studies were carried out in the Department of Molecular Medicine and Cell Technologies of the RSNPMC of Hematology. Association analysis of the rs1042713 and rs1042714 polymorphisms of the ADRB2 gene was carried out using a case-control model.

The results obtained by the authors allow us to conclude that the homozygous Glu/Glu genotype plays an important role in the pathogenesis of nosological syntropy of cholelithiasis and metabolic syndrome. The risk of developing cholelithiasis with MS when carrying this genotypic variant of the ADRB2 gene can significantly increase by more than 3.5 times. The homozygous Gln/Gln genotype indicates a protective effect in the formation of cholelithiasis with a combination of MS.

Polymorphism rs 1042713 of the ADRB2 gene does not allow the use of this locus as a genetic marker for predicting the risk of developing MS in patients with cholelithiasis.

Keywords: molecular genetic relationship of cholelithiasis, metabolic syndrome, Glu/Glu homozygous genotype, ADRB2 genotypic variant

First page

514

Last page

519

For citation: Ismailov O.S., Batirov D.Yu., Rakhimov A.P., Azadov B.R., Yusupov D.D., MOLECULAR GENETIC INTERRELATION OF GALLSTONE DISEASE AND METABOLIC SYNDROME //New Day in Medicine 9 (47)2022 514-519 https://l.clck.bar/b5281

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