92 -9 (47)2022 — Rakhmatov Olim Bobomurodovich — STUDYING THE EFFECT OF THE IMMUOMODULATOR GEPON ON TNF-α IN THE SERUM OF THE BLOOD OF PATIENTS WITH CUTANEOUS LEISHMANIASIS

STUDYING THE EFFECT OF THE IMMUOMODULATOR GEPON ON TNF-α IN THE SERUM OF THE BLOOD OF PATIENTS WITH CUTANEOUS LEISHMANIASIS

Rakhmatov O. B. Bukhara State Medical Institute, Bukhara, Uzbekistan

Rezyume

Observations were carried out in 50 patients with cutaneous (zonootic) leishmaniasis aged from 1 to 40 years. The diagnosis of cutaneous leishmaniasis in all patients was confirmed by clinical, epidemiological and parasitological methods.When studying the level of TNF-α (a-factor of tumor necrosis) in the blood before and after oral and local use of the immunomodulator “Gepon” for 15 days, the content of TNF-α in 26 patients of the main group significantly changed compared to 24 patients in the control group. The study of the level of TNF-α in blood serum by age and by the number of wounds found that the amount of TNF-α level in persons younger than 20 years was significantly different from that in persons aged 20–40 years.

Key words: zoonotic leishmaniasis; immunomodulator Gepon; TNF– α (factor of tumor necrosis– α).

First page

544

Last pagr

549

For citation:Rakhmatov O. B.STUDYING THE EFFECT OF THE IMMUOMODULATOR GEPON ON TNF-α IN THE SERUM OF THE BLOOD OF PATIENTS WITH CUTANEOUS LEISHMANIASIS //New Day in Medicine 9(47)2022 544-549 https://clck.ru/32MTBa

LIST OF REFERENCES

1. Raxmatov O.B., Obloqulov A.R.Evaluation of changes in blood lymphocytes when using gepon immunomodulators in patients with skin leishmaniosis. Журнал новый день в медицине 2022 год 2(40) стр. 76-81.
2. Olim Bobomurodovich Rakhmatov,  Improving the principles of treatment in patients with zoonotic leis’hmaniasis with the immunomodulator gepon and methylene blue using the alt-vostok device.,  2021/9, jurnal 湖南大学学报 (自然科学版) tom 48, nomer 9
3. Farxod A Maxmudov, Olim B Raxmatov, Ixtiyor I Latipov, Mirabbos K Rustamov, Gulnoza S S’harapova,Intravenous laser blood irradiation in the complex treatment of patients with cutaneous leis’hmaniasis. data publikatsii 2021/9, jurnal 湖南大学学报 (自然科学版), tom 48, nomer 9
4. Дранник Г.Н. Клиническая иммунология и аллергология: пособие / Г.Н. Дранник. – 4-е изд., доп. – К.: Полиграф плюс, 2010.- 547 с.
5. The use of “Sulfatcet-r”–gel in combination with zinc ointment to determine its yeffectiveness against acne disease. O.B Raxmatov, N.D Xayitova, 2021/12/4, Central asian journal of medical and natural sciences, tom 2, nomer 6, стр. 227-230.
6. O.B Raxmatov, N.D Xayitova,  To identify genetic tendency of tendency of    teenagers to acne and to yevaluate the yefficiency of zinc for the purpose of it’s prophylactic. 2020, jurnal // Новый день в медицине 4, стр. 129-132.
7. J.H. Ozodov, O.B. Raxmatov, Analysis of registered patients diagnosed with gonorrhea in bukhara region and a method for comparing the yeffectiveness of the drugs used depending on the clinical course of  // Журнал новый день в медицине №4, стр, 293-297. 2020.
8. O.B Raxmatov, J. X Ozodov, N.D Xayitova, Patients with a diagnosis of gonorrhea are registered in bukhara region and depending on the clinical course of the disease, separation into age and gender. data publikatsii, 2020, // Журнал новый день в медицине №1, стр. 347-350
9. Buxoro viloyatida atopik dermatit kasalligi bilan kasallanganlarning yoshga va jinsga nisbatan ajratilishi O.B Raxmatov, D.A Yusupov, 2021, Журнал новый день в медицине №2, стр. 1718-1729
10. Improving the principles of treatment in patients with zoonotic leis’hmaniasis with the immunomodulator gepon and methylene blue using the alt vostok apparatus. Rakhmatov Olim Bobomurodovich, Khus’hvaktova Madina Farkhodovna, data publikatsii 2021/1/31, jurnal the american journal of medical sciences and pharmaceutical research, tom-3, №01, стр. 147-151
11. Assessment of skin and mucosal changes during acute illness and remission of Сovid-19 patients. M.F Xus’hvaqtova, O.B Raxmatov, data publikatsii 2021/10/30, jurnal Central asian journal of medical and natural sciences, stranisi 288-291
12. Ранняя диагностика и совершенствование принципов лечения у болных с кожным лейшманиозом. Олим Бобомуродович Рахматов, Мадина Фарходовна Хушвақтова, дата публикации 2018, журнал Биология и интегративная медицина, №11
13. Leyshmanioz, epidemiologiya, klinik namoyon bo‘lishi, diagnostika va davosi.  A.Yu. Rodin, A.V. Smirnov.  Vestnik VolGMU, стр.  181-183.
14. Synthetic and natural immunomodulators acting as interferon inducers.  Silin, D.S., Lyubomska, O.V., Yers’hov, F.I., Frolov, V.M., Kutsyna, G.,  Current pharmaceutical design, 2009. 15(11): p. 1238-1247. DOI: 10.2174/138161209787846847.
15. Иммуномодуляторы Иммуномакс и Гепон в комплексном лечении болных с острой гнойной хирургической инфекцией Чадаев, А.П., Нурписов, А.М., Пичугин, А.В., Атауллаханов, Р.И., . Русский медицинский журнал, 2004. 12(24): п. 1427-1433.
16. Experimental and clinical study of immunomodulators Immunomax and Gepon in complex treatment of acute purulent surgical infection.Chadaev, A.P., Nurpisov, A.M.,  Antibiotiki i khimioterapiia [Antibiotics chemoterapy], 2004. 49(7): p. 9-16.
17. The biogenesis and properties of the parasitophorous vacuoles that harbour Leis’hmania in murine macrophages. (Antoine J. C., Prina Ye., Lang T., Courret N.  (angl.) // Trends in microbiology. — 1998. — Vol. 6, no. 10. — P. 392—401. — PMID 9807783.)
18. Subversion of host cell signalling by the protozoan parasite Leis’hmania. (Gregory D. J., Olivier M.  (angl.) // Parasitology. — 2005. — Vol. 130 Suppl. — P. 27—35. — doi: 10.1017/S0031182005008139. — PMID 16281989. )
19. The immunopathogenesis of atopic dermatitis and strategy of immunotherapy. Maxmudov, F. A., & Latipov, I. I. (2019). Новый день в медицине, (4), 53-57.
20. Hoofnagle J.H. Therapy of viral hepatitis / J.H. Hoofnagle // Digestion. — 1998. — № 59. — Р. 563—578.