23 -10 (48) 2022 — Rakhimov A.N., Kamilova U.K. — FEATURES OF THE COURSE OF THE DISEASE AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC HEART FAILURE AFTER COVID-19

FEATURES OF THE COURSE OF THE DISEASE AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC HEART FAILURE AFTER COVID-19

Rakhimov A.N.,“Republica Scientific and Applied Medical Center of Specialized Therapy and Medical Rehabilitation” DM Tashkent, Uzbekistan

Kamilova U.K., “Republica Scientific and Applied Medical Center of Specialized Therapy and Medical Rehabilitation” DM Tashkent, Uzbekistan

Zakirova G.A.“Republica Scientific and Applied Medical Center of Specialized Therapy and Medical Rehabilitation” DM Tashkent, UzbekistanResume

Due to damage to endothelial cells by SARS-CoV-2 viruses, the levels of renin-angiotensin and aldosterone humoral factors were significantly higher in patients with CHF who underwent COVID-19 than in patients with CHF who did not have COVID-19. In addition, a strong correct correlation of these neurohormones with other factors, the levels of C-reactive protein, fibrinogen and D-dimer, was established. A prognostic matrix was created based on the results of cardiovascular risk factors, the clinical course of the disease and the results of laboratory functional methods.

Key words: chronic heart failure, post-COVID syndrome, endothelial dysfunction, prognostic matrix.

First page

133

Last page

139

For citation:Rakhimov A.N., Kamilova U.K., Zakirova G.A.FEATURES OF THE COURSE OF THE DISEASE AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC HEART FAILURE AFTER COVID-19 //New Day in Medicine 10(48)2022 133-139 https://clck.ru/32TfX5

LIST OF REFERENCES:

1. Amraei R., Rahimi N. COVID-19, Renin-Angiotensin System and Endothelial Dysfunction. // Cells. 2020 Jul 9;9(7):1652.
2. Carod-Artal F.J. Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved. // Rev Neurol. 2021 Jun 1;72(11):384-396. English, Spanish.
3. Carod-Artal F.J. Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved. // Rev Neurol. 2021 Jun 1;72(11):384-396. English, Spanish. https://covid19.who.int/#:~:text=Globally%2C%20as%20of%206%3A20pm,vaccine%20doses%20have%20been%20administered.
4. Ni W., Yang X., Yang D., Bao J., Li R. et al. Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. // Crit Care. 2020 Jul 13; 24(1):422.
5. Rey J.R., Caro-Codón J., Rosillo S.O., Iniesta Á.M. et al. CARD-COVID Investigators. Heart failure in COVID-19 patients: prevalence, incidence and prognostic implications. // Eur J Heart Fail. 2020 Dec; 22(12):2205-2215.
6. Richter D., Guasti L., Koehler F., Squizzato A. et al. Late phase of COVID-19 pandemic in General Cardiology. A position paper of the ESC Council for Cardiology Practice. // ESC Heart Fail. 2021 Oct;8(5):3483-3494.
7. Salah H.M., Fudim M., O’Neil S.T., Manna A., Chute C.G., Caughey M.C. Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study. // Nat Commun. 2022 Jul 15;13(1):4117.
8. Santoro L., Falsetti L., Zaccone V., Nesci A. et al. Against Covid-Post-Acute Care Study Group. Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study. // J Clin Med. 2022 Mar 23;11(7):1774.