• Home
  • NEW DAY MEDICINE
  • 10 (48) 2022
  • 27 -10 (48) 2022 — A.A.Yariyev , K.T. Boboev, — ASSOSIATION OF TGF-Β1 AND MTHFR POLYMORPHISMS WITH VARICOSE VEIN DISEASE AND ITS THROMBOTIC COMPLICATIONS

27 -10 (48) 2022 — A.A.Yariyev , K.T. Boboev, — ASSOSIATION OF TGF-Β1 AND MTHFR POLYMORPHISMS WITH VARICOSE VEIN DISEASE AND ITS THROMBOTIC COMPLICATIONS

ASSOSIATION OF TGF-Β1 AND MTHFR POLYMORPHISMS WITH VARICOSE VEIN DISEASE AND ITS THROMBOTIC COMPLICATIONS

A.A.Yariyev, Republican Research Center of Emergency Medicine, Syrdarya Branch Ministry of Health of the Republic of Uzbekistan

K.T. Boboev, Republican Specialized Scientific-Practical Medical Center of Hematology Tashkent, Ministry of Health of the Republic of Uzbekistan

Mohammad Din A.Republican Specialized Scientific-Practical Medical Center of Hematology Tashkent, Ministry of Health of the Republic of Uzbekistan

Resume

This article presents the results of studying the role of TGF-β1 gene polymorphism and MTHFR gene polymorphism in the development of lower extremity varicose veins and its complications.

The aim of the study was to identify the association of TGF-β1 and MTHFR genes with the development of varicose veins and its thrombotic complications.

Materials and methods. The study involved 316 people, of which 161 were included in the main and 155 in the control group.

Results. The heterozygous G/C genotype of the TGF-β1 gene was significantly more often detected among patients with venous thrombosis, which almost fourfold increased the risk of developing the disease in the group of patients with venous thrombosis (χ2>3.84; p<0.05; OR=3.9; 95% CI: 1.64- 8.98). (p<0.05). The proportion of the mutant homozygous T/T genotype of the MTHFR gene also significantly predominated in the group of patients with venous thrombosis (χ2>3.84; p<0.05; OR=3.1; 95% CI: 1.11-8.49).

Conclusions. The presence of the heterozygous G/C genotype of the TGF-β1 gene and the homozygous T/T genotype of the MTHFR gene has diagnostic and prognostic significance and increases the risk of developing VLVD complicated by venous thrombosis.

Keywords: TGF-β1 gene, rs1800471 polymorphism, MTHFR gene, rs1801133, LVH, thrombotic complications, venous thrombosis.

First page

156

Last page

160

For citation:A.A.Yariyev , K.T. Boboev, Mohammad Din A.- ASSOSIATION OF TGF-Β1 AND MTHFR POLYMORPHISMS WITH VARICOSE VEIN DISEASE AND ITS THROMBOTIC COMPLICATIONS //New Day in Medicine 10(48)2022 156-160 https://clck.ru/32TqH9

LIST OF REFERENCES:

  1. Stubbs MJ, Mouyis M, Thomas M. Deep vein thrombosis. // BMJ. 2018 Feb 22;360:k351. doi: 10.1136/bmj.k351. Erratum in: BMJ. 2018 Mar 21;360:k1335. PMID: 29472180.
  2. Müller-Bühl U, Leutgeb R, Engeser P, Achankeng EN, Szecsenyi J, Laux G. Varicose veins are a risk factor for deep venous thrombosis in general practice patients. // Vasa. 2012 Sep;41(5):360-5. doi: 10.1024/0301-1526/a000222. PMID: 22915533
  3. Chang SL, Huang YL, Lee MC, Hu S, Hsiao YC, Chang SW, Chang CJ, Chen PC. Association of Varicose Veins With Incident Venous Thromboembolism and Peripheral Artery Disease. // JAMA. 2018 Feb 27;319(8):807-817. doi: 10.1001/jama.2018.0246. PMID: 29486040; PMCID: PMC5838574
  4. Weiss A., Attisano L. The TGFbeta superfamily signaling pathway. Wiley Interdiscip Rev Dev Biol. 2013 Jan-Feb;2(1):47-63. doi: 10.1002/wdev.86. Epub 2012 Oct 5. PMID: 23799630
  5. Liew S.C., Gupta E.D. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases. // Eur J Med Genet. 2015 Jan;58(1):1-10. doi: 10.1016/j.ejmg.2014.10.004. Epub 2014 Nov 4. PMID: 25449138.
  6. Xu J., Li K., Zhou W. Relationship between genetic polymorphism of MTHFR C677T and lower extremities deep venous thrombosis. // Hematology. 2019 Dec;24(1):108-111. doi: 10.1080/10245332.2018.1526440. Epub 2018 Oct 10. PMID: 30303041.
  7. Saeed A., Sumreen M., Kashif M.A. (2015) To determine the fre-quency of Factor V Leiden in cases of Deep Vein Thrombosis and Healthy controls. // Pak J Med Sci 31(5):1219
  8. Dölek B., Eraslan S., Eroğlu S., Kesim B.E., Ulutin T., Yalçıner A., Laleli Y.R., Gözükirmızı N. (2007) Molecular analysis of factor V Leiden, factor V Hong Kong, factor II G20210A, methylenetet-rahydrofolate reductase C677T, and A1298C mutations related to Turkish  thrombosis  patients.  // Clin  Appl  Thromb/Hemost  13(4):435–438
  9. Jacob T., Hingorani A., Ascher E. Overexpression of transforming growth factor-beta1 correlates with increased synthesis of nitric oxide synthase in varicose veins. // J Vasc Surg. 2005 Mar;41(3):523-30. doi: 10.1016/j.jvs.2004.12.044. PMID: 15838489
  10. Lee S, Lee W, Choe Y, Kim D, Na G, Im S, Kim J, Kim M, Kim J, Cho J. Gene expression profiles in varicose veins using complementary DNA microarray. // Dermatol Surg. 2005 Apr;31(4):391-5. doi: 10.1111/j.1524-4725.2005.31103. PMID: 15871312.
  11. Kowalewski R., Malkowski A., Sobolewski K., Gacko M. Evaluation of transforming growth factor-beta signaling pathway in the wall of normal and varicose veins. // Pathobiology. 2010;77(1):1-6. doi: 10.1159/000272948. Epub 2010 Feb 25. PMID: 20185961
  12. Ehsani M., Imani A., Moravveji A. Prevalence of factor V leiden, MTHFR C677T and MTHFR A1298C polymorphisms in patients with deep vein thrombosis in Central Iran. Mol Biol Rep. 2018 Aug;45(4):621-624. doi: 10.1007/s11033-018-4201-0. // Epub 2018 May 31. PMID: 29855758.
  13. Li A., Huang W., Yang Q., Peng L,. Liu Q. Expression of the C677T Polymorphism of the 5, 10-Methylenetetrahydrofolate Reductase (MTHFR) Gene in Patients with Carotid Artery Atherosclerosis. Med Sci Monit. 2020 Jul 17;26:e920320. doi: 10.12659/MSM.920320. PMID: 32675800; // PMCID: PMC7387044.
  14. Gogu A.E., Jianu D.C., Dumitrascu V., Ples H., Stroe A.Z., Docu Axelerad D., Docu Axelerad A. MTHFR Gene Polymorphisms and Cardiovascular Risk Factors, Clinical-Imagistic Features and Outcome in Cerebral Venous Sinus Thrombosis. // Brain Sci. 2020 Dec 27;11(1):23. doi: 10.3390/brainsci11010023. PMID: 33375456; PMCID: PMC7824001.
  15. Lupi-Herrera E., Soto-López M.E., Lugo-Dimas A.J., Núñez-Martínez M.E., Gamboa R., Huesca-Gómez C., Sierra-Galán L.M., Guarner-Lans V. Polymorphisms C677T and A1298C of MTHFR Gene: Homocysteine Levels and Prothrombotic Biomarkers in Coronary and Pulmonary Thromboembolic Disease. Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029618780344. doi: 10.1177/1076029618780344. // Epub 2018 Jun 19. PMID: 29916259; PMCID: PMC6714945.

file

download