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  • 28 -10 (48) 202 — Sultanova Sh.T., Froyantchenko G.A. — THE RANGE OF MICRO -DELICIA OF THE Y CHROMOSOMES, INCLUDING THE AZOOSPERMIA FACTOR (AZF) IN CHILDREN AND ADOLESCENTS WITH SEXUAL DEVELOPMENT DISORDERS

28 -10 (48) 202 — Sultanova Sh.T., Froyantchenko G.A. — THE RANGE OF MICRO -DELICIA OF THE Y CHROMOSOMES, INCLUDING THE AZOOSPERMIA FACTOR (AZF) IN CHILDREN AND ADOLESCENTS WITH SEXUAL DEVELOPMENT DISORDERS

THE RANGE OF MICRO -DELICIA OF THE Y CHROMOSOMES, INCLUDING THE AZOOSPERMIA FACTOR (AZF) IN CHILDREN AND ADOLESCENTS WITH SEXUAL DEVELOPMENT DISORDERS

Sultanova Sh.T., Republican Specialized Scientific and Practical Center for Endocrinology of the Republic of Uzbekistan named after Acad Y.Kh. Turakulov.,

Froyantchenko G.A., Tashkent State Dental Institute

Dalimova G.A. , Republican Specialized Scientific and Practical Center for Endocrinology of the Republic of Uzbekistan named after Acad Y.Kh. Turakulov.,

Alieva D.A.Republican Specialized Scientific and Practical Center for Endocrinology of the Republic of Uzbekistan named after Acad Y.Kh. Turakulov.,

Resume

Introduction. The problem of studying the microdelias of Y chromosome, including AZF’s locus in children and adolescents, is relevant, however, there are very few corresponding studies in the literature.The purpose of the study is to study the spectrum of microdelias of the chromosomes, including the analysis of the structure of the AZF -Lokus and deletion of the SRY gene in boys and adolescents with complicated forms of cryptorchidism (K).Materials and methods in 5 boys and adolescents conducted a general clinical, general and special andrological study, cytogenetic, molecular genetic examination (PCR), magnetic resonance imaging The results.   High effectiveness (in 3 out of 5 cases) detection of microdeleciya of Y chromosomes with AZF Lokus deeds in the presented patients indicates the need to continue research in this direction and recommendation to expand the testing of the AZF of the AZF Lokus Y chromosome of boys and adolescents with sexual developmental disorders . Conclusions.  The high effectiveness of detection of  microdeleciya    in the presented patients indicates the need to continue research in this direction and recommendations for expanding the testimony of testing AZF Locus Y Chromosomes of boys and adolescents with puberty developmental development.

Key words: AZF-Lock, Y chromosome of deletion, hypogonadism, cryptorchidism, fertility.

First page

161

Last page

167

For citation:ultanova Sh.T., Froyantchenko G.A. Dalimova G.A. , Alieva D.A. – THE RANGE OF MICRO -DELICIA OF THE Y CHROMOSOMES, INCLUDING THE AZOOSPERMIA FACTOR (AZF) IN CHILDREN AND ADOLESCENTS WITH SEXUAL DEVELOPMENT DISORDERS //New Day in Medicine 10(48)2022 161-167 https://clck.ru/32TqQP

LIST OF REFERENCES:

  1. Зобкова Г.Ю., Баранова Е.Е., Донников А.Е. и др. Спектр делеций фактора азооспермии (AZF) у мужчин с нормальным и нарушенным сперматогенезом // Проблемы репродукции. -2017.- № 4. С.109-113.
  2. Немцова М.В. Данцев И.С., Михайленко Д.С., Лоран О.Б. Генетические аспекты синдрома тестикулярной дисгенезии и составляющих его состояний // Онкоурология.-2018.- №3.-Т.14. С.92-104.
  3. Окулов А.Б., Мираков К.К., Володько Е.А. и др. Крипторхизм – ретроспектива и вопросы настоящего времени. // Детская хирургия. – 2017. -Т. 21.- № 4. -С. 202-206.
  4. Тавокина Л.В. Мужское бесплодие. Генетические бесплодие //Почки. -2014. -№2 (8) www.mif-ua.com. С.9-13.
  5. Тулеева Л.М., Аралбаева А.Н. Роль делеций гена АZF в развитии мужского бесплодия //MEDICINE. -2015. № 7. С.42-45
  6. Черных В.Б., Курило Л.Ф, Шилейко Л.В. и др . Анализ микроделеций в локусе AZF у мужчин с бесплодием: совместный опыт исследований // Медицинская генетика. -2003. – Т.2. №8.-С. 367-379.
  7. Черных В.Б. AZF делеции — частая генетическая причина бесплодия у мужчин: современное состояние исследований // Проблемы репродукции. – 2009. – №1. – С.10-14.
  8. Шабалов Н.П. Диагностика и лечение эндокринных заболеваний у детей и подростков. Москва 2017. 408 с
  9. Attalla K., Arnone E., Williot P., Greenfield S. Cryptorchidism: experience and reason // Can J Urol.- 2017 – Vol.24(4). – Р8941-8945.
  10. Giachini C., Nuti F., Marinari E., Forti G., Krausz C. Partial AZFc deletions in infertile men with cryptorchidism // Hum Reprod. 2007 Sep;22(9): P. 2398-403
  11. Kang Z., Qiao N., Tan Z., Tang Z., Li Y. Expression patterns and changes of the LCN2 gene in the testes of induced cryptorchidism and busulfan-treated mice // Syst BiolReprod Med. – 2017; 63(6) P.364-369.
  12. Guimei Yao, Guian Chen Tianming Pan Study of Microdeletions in the Y Chromosome of Infertile Men with Idiopathic Oligo- or Azoospermia // Journal of Assisted Reproduction and Genetics volume 18, pages612–616 (2001)
  13. Wiwat Rodprasert, Helena E. Virtanen, Juho-Antti Mäkelä, and Jorma Toppari. Hypogonadism and Cryptorchidism // Front Endocrinol (Lausanne). 2019; 10: 906. Published online 2020 Jan 15. Doi: 10.3389/fendo.2019.00906
  14. Radmayr C., Dogan H.S., Hoebeke P. et al. Management of undescended testes: European association of urology /European society for paediatric urology guidelines. // Journal of Pediatric Urology. 2016;12(6):335–343. doi: 10.1016/j.jpurol.2016.07.014. 
  15. Beata Vincel, Gilvydas Verkauskas,Vytautas Bilius,Darius Dasevicius, Dalius Malcius, et al. Gonadotropin-Releasing Hormone Agonist Corrects Defective Mini-Puberty in Boys with Cryptorchidism: A Prospective Randomized Study // Biomed Res Int. 2018; 2018: 4651218. Published online 2018 Jul 3. doi: 10.1155/2018/4651218

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