51 -10 (48) 2022 — Irgashev D.S., Gasanova Sh.S. — MOLECULAR GENETIC BASIS OF MALE INFERTILITY Ile462Val POLYMORPHISM OF THE CYP1A1 GENE IN THE DEVELOPMENT OF MALE INFERTILITY

MOLECULAR GENETIC BASIS OF MALE INFERTILITY Ile462Val POLYMORPHISM OF THE CYP1A1 GENE IN THE DEVELOPMENT OF MALE INFERTILITY

Irgashev D.S., «Doctor-D-IVF» LLC

Gasanova Sh.S., «Doctor-D-IVF» LLC

Boboev K.T. Republican Specialized Scientific-Practical Medical Center of Hematology

Resume

Male infertility is an actual problem of modern andrology and makes a significant contribution (about 50%) to infertile marriages and approximately 8-12% of couples worldwide suffer from this pathology. The most common genomic changes that cause reproductive disorders in men are quantitative disorders of sex chromosomes. An essential factor in the formation of male infertility from the standpoint of evidence-based medicine are disorders in the system of xenobiotic detoxification genes. The role of the Ile462Val polymorphism of the CYP1A1 gene in the formation of male infertility was analyzed. The study was conducted on a sample of 140 patients with various clinical forms of male infertility and 155 conditionally healthy fertile men. The obtained results of the study indirectly indicate the dysregulatory effect of the unfavorable allelic variant of this polymorphism on the expression of cytochrome CYP1A1.

Keywords: male infertility, xenobiotic biotransformation genes, chromosomal mutations, non-obstructive azoospermia, polycyclic aromatic hydrocarbons (PAH), cytochrome P450.

First page

279

Last page

285

For citation:Irgashev D.S., Gasanova Sh.S. Boboev K.T. – MOLECULAR GENETIC BASIS OF MALE INFERTILITY Ile462Val POLYMORPHISM OF THE CYP1A1 GENE IN THE DEVELOPMENT OF MALE INFERTILITY //New Day in Medicine 10(48)2022 279-285 https://clck.ru/32XGH8

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