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  • 53 -10 (48) 2022 — A.A. Yariev, S.S. Khudoyberdiev — RELATIONSHIP OF TGF-Β1 AND MTHFR GENE POLYMORPHISM WITH THE DEVELOPMENT OF VARICOSE DISEASE AND ITS THROMBOTIC COMPLICATIONS

53 -10 (48) 2022 — A.A. Yariev, S.S. Khudoyberdiev — RELATIONSHIP OF TGF-Β1 AND MTHFR GENE POLYMORPHISM WITH THE DEVELOPMENT OF VARICOSE DISEASE AND ITS THROMBOTIC COMPLICATIONS

RELATIONSHIP OF TGF-Β1 AND MTHFR GENE POLYMORPHISM WITH THE DEVELOPMENT OF VARICOSE DISEASE AND ITS THROMBOTIC COMPLICATIONS

A.A. Yariev, Syrdarya branch of the Republican Scientific Center for Emergency Medical Care, Gulistan, Uzbekistan

S.S. Khudoyberdiev, Syrdarya branch of the Republican Scientific Center for Emergency Medical Care, Gulistan, Uzbekistan

K.T. Boboev, Republican Specialized Scientific and Practical Medical Center for Hematology, Tashkent, Uzbekistan

A. Mohammad Din, Republican Specialized Scientific and Practical Medical Center for Hematology, Tashkent, Uzbekistan

B.I. Shukurov Republican Scientific Center of Emergency Medical Care, Tashkent, Uzbekistan

Resume

Aim. Identification the association of TGF-β1 and MTHFR genes with the development of lower extremity varicose disease and its thrombotic complications.

Material and methods. 161 patients with varicose disease (main group) were examined: 111 patients without thrombotic complications, 50 with phlebothrombosis. The control group included 155 conditionally healthy individuals. We studied the frequency of carriage of the G/G, G/C, C/C genotypes of the rs1800471 polymorphism in the TGF-β1 gene and the C/C, C/T, T/T genotypes of the rs1801133 polymorphism in the MTHFR gene.

Results. Among patients with venous thrombosis, the frequency of carriage of the heterozygous G/C genotype TGF-β1 gene and the mutant homozygous T/T genotype MTHFR gene was almost 4 times higher than in control group (χ2>3.84; p<0.05; OR=3.9; 95% CI:1.64 -8.98 and χ2>3.84; p<0.05; OR=3.1; 95%CI: 1.11-8.49, respectively).

Conclusions. The presence of the heterozygous G/C genotype of the TGF-β1 gene and the homozygous T/T genotype of the MTHFR gene has diagnostic and prognostic significance and greatly increases the risk of developing varicose disease and phlebothrombosis.

Keywords: TGF-β1 gene, rs1800471 polymorphism, MTHFR gene, rs1801133, varicose disease, thrombotic complications, venous thrombosis.

First page

291

Last page

295

For citation:A.A. Yariev, S.S. Khudoyberdiev, K.T. Boboev, A. Mohammad Din, B.I. Shukurov RELATIONSHIP OF TGF-Β1 AND MTHFR GENE POLYMORPHISM WITH THE DEVELOPMENT OF VARICOSE DISEASE AND ITS THROMBOTIC COMPLICATIONS //New Day in Medicien 10(48)2022 291-295 https://clck.ru/32XGRY

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