60 -10 (48) 2022 — K.Kh.Akhmedov, M.A.Ergashov — FEATURES OF THE RHEOLOGICAL PROPERTIES OF BLOOD OF ANIMALS IN THE DYNAMICS OF EXPERIMENTAL CHOLESTASIS
FEATURES OF THE RHEOLOGICAL PROPERTIES OF BLOOD OF ANIMALS IN THE DYNAMICS OF EXPERIMENTAL CHOLESTASIS
K.Kh.Akhmedov, Termez branch of the Tashkent Medical Academy
M.A.Ergashov, Termez branch of the Tashkent Medical Academy
L.R.Babayeva. Termez branch of the Tashkent Medical Academy
Resume
The problem of effective treatment of patients with obstructive jaundice remains relevant, despite the impressive results of biliary surgery. The main cause of mortality in patients with benign obstructive jaundice is the progression of liver failure after surgery on the biliary tract.
Purpose of the study: To determine the features of the blood velocity of animals in the dynamics of experimental cholestasis.
Material and methods. The experiments were carried out on 69 outbred male rats of a mixed population with an initial weight of 180-200 g, kept in a laboratory diet in a vivarium.
Results. In the experimental group of animals, we revealed an even greater increase in blood hyperviscosity, while the shear rate slightly increased relative to the values of the previous study period. So, the shear rate was at applied pressures of 8, 12 and 16 mm.aq.st lower than the value of intact rats by 60; 80.56 and 73.5% respectively.
Conclusion. The results of the studies indicate that the violation of the rheological properties of blood as a result of ligation of the common bile duct is of a transient nature. These results to a certain extent explain the disturbances in the microcirculation system of the studied organs.
Keywords: experiment, cholestasis, blood flow velocity, bile duct obstruction
First page
324
Last page
327
For citation: K.Kh.Akhmedov, M.A.Ergashov, L.R.Babayeva. – FEATURES OF THE RHEOLOGICAL PROPERTIES OF BLOOD OF ANIMALS IN THE DYNAMICS OF EXPERIMENTAL CHOLESTASIS //New Day in Medicine 10(48)2022 324-327 https://clck.ru/32XpNu
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