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  • 42 — 11 (49) 2022 — Akhmedzhanova Kh.Z., Olimova K.Zh. — EVALUATION OF THE EFFECTIVENESS OF CLOMIPHENE CITRATE CONTAINING SUBSTANCES IN STIMULATION OF OVULATION IN WOMEN OF LATE REPRODUCTIVE AGE WITH LOW OVARIAN RESERVE

42 — 11 (49) 2022 — Akhmedzhanova Kh.Z., Olimova K.Zh. — EVALUATION OF THE EFFECTIVENESS OF CLOMIPHENE CITRATE CONTAINING SUBSTANCES IN STIMULATION OF OVULATION IN WOMEN OF LATE REPRODUCTIVE AGE WITH LOW OVARIAN RESERVE

EVALUATION OF THE EFFECTIVENESS OF CLOMIPHENE CITRATE CONTAINING SUBSTANCES IN STIMULATION OF OVULATION IN WOMEN OF LATE REPRODUCTIVE AGE WITH LOW OVARIAN RESERVE

Akhmedzhanova Kh.Z., Tashkent Media Academy, Uzbekistan

Olimova K.Zh., Tashkent Media Academy, Uzbekistan

Shukurov F.I.Tashkent Media Academy, Uzbekistan

Resume

Objective: to evaluate the effectiveness of the use of clomiphene citrate-containing drug in ovulation stimulation in women of late reproductive age with low ovarian reserve.

Materials and methods. The study included 60 women with reduced ovarian reserve, of which: 1 – the main group included – 30 women with low ovarian reserve and II – 30 women with extremely low ovarian reserve treated with clomiphene citrate containing a drug for ovarian stimulation, the comparison group consisted of – 20 women with a similar pathology, but refused to take a clomiphene-containing drug. All patients were prescribed clomiphene citrate containing substances to stimulate ovulation. The assessment of the ovarian reserve in women was carried out by assessing its biochemical and echographic markers.

Results. In group I patients, ovulation was achieved in 23 (76.7%) patients. Of these, 2 (11.7%) ovulated after the second cycle at a dose of 100 mg and in 5 (29.4%) after the third month of ovulation at a dose of 150 mg of clomiphene citrate-containing drug per day. Pregnancy occurred in 15 (73.0%) patients of this group: in one patient in the first cycle of treatment when taking 50 mg of clomiphene citrate-containing preparation, in the second in the third cycle of ovulation stimulation at a dose of 100 mg of this drug. In the 2nd group of patients, ovulation was achieved in 21 (70.0%) patients. Three (10%) and two (6.7%) of them ovulated after the second and third months of stimulation using 100-150 mg of clomife-containing drug per day. Pregnancy occurred in 15 (66.7%) patients of this group. Pregnancy in the comparison group occurred in 3 (15.0%) patients.

 Conclusion. The use of clomiphene citrate-containing drug in women from late reproductive age with low and extremely low ovarian reserve leads to the induction of ovulation in 76.7% and 70.0% of women, and the onset of pregnancy in 73.0% and 66.7% of women, respectively.

Key words: late reproductive age, ovarian reserve, ovulation stimulation, clomiphene citrate containing substances.

First page

233

Last page

237

For citation: Akhmedzhanova Kh.Z., Olimova K.Zh., Shukurov F.I. – EVALUATION OF THE EFFECTIVENESS OF CLOMIPHENE CITRATE CONTAINING SUBSTANCES IN STIMULATION OF OVULATION IN WOMEN OF LATE REPRODUCTIVE AGE WITH LOW OVARIAN RESERVE //New Day in Medicine 11(49)2022 233-237 https://clck.ru/32kVL6

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