51 -11 (49) 2022 — Nishonov Yu.N., Mamasaidov J.T. — COMPARATIVE ASSESSMENT OF THE RESPIRATION AND OXIDATIVE PHOSPHORYLATION INTENSITY IN THE EXPERIMENT

COMPARATIVE ASSESSMENT OF THE RESPIRATION AND OXIDATIVE PHOSPHORYLATION INTENSITY IN THE EXPERIMENT

Nishonov Yu.N., Ferghana Medical Institute of Public Health

Mamasaidov J.T. Ferghana Medical Institute of Public Health

Resume

The work is devoted to the study of the intensity of cellular respiration and metabolism in toxic liver damage by chemical factors. In chronic poisoning with the pesticide Fozalon, the intensity of respiration and oxidative phosphorylation with the use of the liver pyruvate substrate decreased in all leads and terms of poisoning. The state of the ADP/0 ratio decreased to 87.7; 80.7; 83.4%. So, the intensity of respiration and oxidative phosphorylation with the addition of pyruvate substrate in liver mitochondria in chronic poisoning with Fosalon was suppressed. The specific biochemical mechanisms of the toxic effect of a separate representative of organophosphorus pesticides – Fosalon and, in general, the entire group of these compounds still remain unclear.

However, we have experimentally studied the main patterns of the development of biochemical disorders in the body of experimental animals under the influence of Fosalon, their orientation, depth and sequence give additional valuable information to the hands of hygienists, toxicologists, researchers, clinicians, which can be used to select early indicators of intoxication – sensitive diagnostic tests, means of prevention and treatment of these intoxications By analyzing the obtained the author drew the appropriate conclusions from the results.

Key words: experiment, toxicology, biologically active substances, phyto preparations, phosphorylation, liver, toxic lesion.

First page

281

Last page

286

For citation: Nishonov Yu.N., Mamasaidov J.T. – COMPARATIVE ASSESSMENT OF THE RESPIRATION AND OXIDATIVE PHOSPHORYLATION INTENSITY IN THE EXPERIMENT //New Day in Medicine 11(49)2022 281-286 https://clck.ru/32nWt5

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