25 -1 (33) 2021 — Rakhmatullaeva M.M., Sharipova Sh.U — ROLE OF MICROORGANISMS AND THEIR METABOLITES IN THE MECHANISM OF PROTECTION OF THE VAGINAL ECOSYSTEM

ROLE OF MICROORGANISMS AND THEIR METABOLITES IN THE MECHANISM OF PROTECTION OF THE VAGINAL ECOSYSTEM

Rakhmatullaeva M.M. -Bukhara State Medical Institute

Sharipova Sh.U. -Bukhara State Medical Institute

Resume

The review article presents literature data on the role of lactobacilli and their metabolites in maintaining a healthy state of the vaginal ecosystem. Changes in metabolites in the reproductive tract are not only due to the dominance of a particular microflora in vaginal dysbiosis, but are also interrelated with changes in the immune system. The study of the interaction between microorganisms, their metabolites and the immune system in the reproductive tract will make it possible to determine the pathogenetic mechanisms of the development of bacterial vaginosis, which will lay the foundation for further research on early diagnosis and effective treatment of the disease.

Key words: lactobacilli, metabolites, vaginal microbiocenosis, Lactobacillus crispatus, Lactobacillus iners

First page

134

Last page

139

For citation: Rakhmatullaeva M.M., Sharipova Sh.U. Role of microorganisms and their metabolites in the mechanism of protection of the vaginal ecosystem//New Day in Medicine 1(33)2021 134-139 https://cutt.ly/LzNj0R3

LIST OF REFERENCES

1. Gladysheva I.V., Cherkasov S.V. Corynebacteria of the vaginal microbiome – potential pathogens or promising probiotics? // Bulletin of the Orenburg Scientific Center of the Ural Branch of the Russian Academy of Sciences. – 2019. – No. 3. – S. 1-20.
2. Nazarova V.V., Shipitsyna E.V., Shalepo K.V., Savicheva A.M. Bacterial communities that form the vaginal microecosystem in normal conditions and in bacterial vaginosis // Journal of Obstetrics and Women’s Diseases. – 2017. – T. 66, No. 6. – P. 30–43.
3. Rakhmatullaeva M.M. The importance of the level of pro-inflammatory cytokines in the development of bacterial vaginosis in women with contraception // Materials of the IV All-Russian scientific-practical conference with international participation “Socially significant and especially dangerous infectious diseases.” – Sochi, 2017. – pp. 196-198.
4. Rakhmatullaeva M.M., Navruzova N.O. Micro biocenosis of the vagina: the role of lactobacilli in its maintenance // Problems of Biology and Medicine. – 2020. – No. 5 (122). – S.269-272.
5. Aldunate M, Srbinovski D, Hearps AC, Latham CF, Ramsland PA, Gugasyan R, et al. Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis. Front Physiol. 2015; 6: 164.
6. Ceccarani C, Foschi C, Parolin C, D’Antuono A, Gaspari V, Consolandi C, et al. Diversity of vaginal microbiome and metabolome during genital infections. Sci Rep. 2019; 9(1):14095.
7. Chen Y, Bruning E, Rubino J, Eder SE. Role of female intimate hygiene in vulvovaginal health: global hygiene practices and product usage. Womens Health (Lond.). 2017; 13(3): 58-67.
8. Сrann SE, Cunningham S, Albert A, Money DM, O’Doherty KC. Vaginal health and hygiene practices and product use in Canada: a national cross-sectional survey. BMC Womens Health. 2018; 18(1) :52.
9. Delgado-Diaz D.J., Tyssen D, Hayward J.A., Gugasyan R., Hearps A.C., Tachedjian G. Distinct immune responses elicited from cervicovaginal epithelial cells by lactic acid and short chain fatty acids associated with optimal and non-optimal vaginal microbiota. Front Cell Infect Microbiol. 2020; 9:446.
10. Doyle R., Gondwe A., Fan Y-M., Maleta K., Ashorn P., Klein N., et al. A Lactobacillus-deficient vaginal microbiota dominates postpartum women in rural Malawi. Appl Environ Microbiol. 2018; 8410-17.
11. France  M.T.,  Mendes-Soares  H.,  Forney L.J. Genomic comparisons  of Lactobacillus crispatus and Lactobacillus iners reveal potential ecological drivers of community composition in the vagina. Appl Environ Microbiol. 2016;82: 7063- 73.
12. Gajer P., Brotman R.M., Bai G., Sakamoto J., Schütte U.M., Zhong X., et al. Temporal dynamics of the human vaginal microbiota. Sci Transl Med. 2012; 4(132): 132-152.
13. Ilhan Z.E., Laniewski P., Thomas N., Roe D.J., Chase D.M., Herbst-Kralovetz M.M. Deciphering the complex interplay between microbiota, HPV, inflammation and cancer through cervicovaginal metabolic profiling. EBioMedicine . 2019; 44: 675-690.
14. Kyongo J.K., Jespers V., Goovaerts O., Michiels J., Menten J., Fichorova R.N., et al. Searching for lower female genital tract soluble and cellular biomarkers: defining levels and predictors in a cohort of healthy Caucasian women. PLoS One.  2012; 7(8): P 439-51.
15. Laghi L., Picone G., Cruciani F., Brigidi P., Calanni F., Donders G., et al. Rifaximin modulates the vaginal microbiome and metabolome in women affected by bacterial vaginosis. Antimicrob. Agents Chemother. 2014; 58(6): 3411–20.
16. Lamont R.F., Sobel J.D., Akins R.A., Hassan S.S., Chaiworapongsa T., Kusanovic J.P., et al. The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG. 2011; 118: 533-549.
17. Li H., Zang Y., Wang C., Li H., Fan A., Han C., Xue F. The interaction between microorganisms, metabolites, and immune system in the female genital tract microenvironment. Front Cell Infect Microbiol. 2020; 10: 609 488.
18. Linhares I.M., Summers P.R., Larsen B., et al. Contemporary perspectives on vaginal pH and lactobacilli. Am. J. Obstet. Gynecol. 2011; 204(2): 120. P1-5.
19. Macklaim J.M., Fernandes A.D., Di Bella J.M., Hammond J., Reid G., Gloor G.B. Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis. Microbiome. 2013; 1:12.
20. McMillan A., Rulisa S., Sumarah M., Macklaim J.M., Renaud J., Bisanz J.E., et al. A multi-platform metabolomics approach identifies highly specific biomarkers of bacterial diversity in the vagina of pregnant and non-pregnant women. Sci Rep. 2015; 5:14174.

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