85 -11 (49) 2022 — T.V. Tyan., D.A. Alieva — FEATURES OF IMMUNOHISTOCHEMICAL STUDY OF KI-67, P53 AND CD138 PARAMETERS IN ENDOMETRIOID CARCINOMA

FEATURES OF IMMUNOHISTOCHEMICAL STUDY OF KI-67, P53 AND CD138 PARAMETERS IN ENDOMETRIOID CARCINOMA

T.V. Tyan., Republican Specialized Scientific and Practical medical center of obstetrics and gynecology, Tashkent, Uzbekistan

D.A. Alieva Republican Specialized Scientific and Practical medical center of obstetrics and gynecology, Tashkent, Uzbekistan

Resume

Endometrioid carcinoma requires a thorough morphological assessment using immunohistochemical research methods, which largely allows the correct development of management tactics for such patients. The principles of therapy for women were selected based on the somatic and genital status, the results of histological and immunohistochemical studies of scrapings of the uterine cavity.

Key words: Endometrial hyperplasia, endometrial histology, postmenopausal uterine bleeding, immunohistochemical markers – CD138, p53, Ki67, selection of therapy.

First page

486

Last page

492

For citation: T.V. Tyan., D.A. Alieva – FEATURES OF IMMUNOHISTOCHEMICAL STUDY OF KI-67, P53 AND CD138 PARAMETERS IN ENDOMETRIOID CARCINOMA //New Day in Medicine 11(49)2022 486-492 https://clck.ru/32serD

LIST OF REFERENCES:

  1. Klinyshkova T.V., Lautenschleger E.V., Frolova N.B., Golovin Yu.V. The role of modern diagnostic capabilities in endometrial hyperplastic processes in peri- and postmenopausal women. Problems of health of women of reproductive age. //Materials of the interregional practical conference. Omsk, 2019, pp. 29–31.
  2. Makhina E.V., Pichigina A.K., Koldysheva E.V., Molodykh O.P., Lushnikova E.L. Diagnostic and prognostic significance of assessing the proliferative activity of endometrial cell populations in hyperplastic and neoplastic processes. Fundamental research. 2014. No. 10(2). pp. 420–427.
  3. Pavlovskaya M.A. Endometrial hyperplasia in women of childbearing age: clinic, diagnosis, pathogenesis and therapy options // Journal of Grodno State Medical University. 2015. No. 2 (50). pp. 123–127.
  4. Chestnova G.P. “Office hysteroscopy” in the diagnosis of endometrial hyperplastic processes in women in the period of prolonged postmenopause // Voen.-med. magazine 2013. No. 10. P. 59–60.
  5. Chernukha G.N., Dumanovskaya M.R. Modern ideas about endometrial hyperplasia // Obstetrics and gynecology. 2013. No. 3. S. 26–32. 16. Chekhoeva A. N. Experience in the use of indinol and epigallate in the complex treatment of benign hyperplastic processes.
  6. Lacey J.V., Sherman M.E., Rush B.B. Absoluta Risk of Endometrial Carcinoma During 20-year Fallow-up Among Women With Endometrial Hyperplasia // О Clin Oncol. 2016. № 28 (5). Р. 788–792.
  7. Lacey J.V., Sherman M.E., Rush B.B. Absoluta Risk of Endometrial Carcinoma During 20-year Fallow-up Among Women With Endometrial Hyperplasia // О Clin Oncol. 2015. № 28 (5). Р. 788–792.
  8. Akhmedov F.K. Peculiarities of cardiac hemodynamic in pregnant women with mild preeclampsia// Europen Science Review. – 2015. – №4-5. – С. 56 -58.
  9. Akhmedov F.K.Modern views on the role of the immune system in the development of preeclampsia// academicia: An International Multidisciplinary Research Journal https://saarj.com/ ISSN: 2249-7137 Vol. 11, Issue 5, May 2021 Impact Factor: SJIF 2021 = 7.492. – Р. 555-562.
  10. Moore E., Shafi M. Endometrial hyperplasia // Obstetrics, Gynaecology and Reproductive Medicine. 2013. №23(3). Р. 88–93.
  11. Zaino R.J., Kauderer J., Trimble C.L., Silverberg S.G., Curtin J.P., Lim P.C., Gallup D.G. Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study // Cancer. 2016. №106(4). Р. 804–811.
  12. Spies J.B., Cooper J.M. et al. Outcome of uterine embolization and hysterectomy for leiomyomas: results of a multicenter study //Amer. J.Obstet. Gynecol.—2004; 191(1): 22-31.

file

download