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  • 22 -12 (50) 2022 — Vasilevsky E.A., Aleinik V.A., — PREVALENCE OF ALLELIC AND GENOTYPICAL VARIANTS OF TNF-Α GENE G4682A POLYMORPHISM IN CHRONIC VENOUS INSUFFICIENCY COMPLICATED BY VENOUS TROPHIC ULCERS

22 -12 (50) 2022 — Vasilevsky E.A., Aleinik V.A., — PREVALENCE OF ALLELIC AND GENOTYPICAL VARIANTS OF TNF-Α GENE G4682A POLYMORPHISM IN CHRONIC VENOUS INSUFFICIENCY COMPLICATED BY VENOUS TROPHIC ULCERS

PREVALENCE OF ALLELIC AND GENOTYPICAL VARIANTS OF TNF-Α GENE G4682A POLYMORPHISM IN CHRONIC VENOUS INSUFFICIENCY COMPLICATED BY VENOUS TROPHIC ULCERS

Vasilevsky E.A., Andijan State Medical Institute, Uzbekistan

Aleinik V.A., Andijan State Medical Institute, Uzbekistan

Musashaikhov Kh.T., Andijan State Medical Institute, Uzbekistan

Dadabaev O.T. Andijan State Medical Institute, Uzbekistan

Resume

Venous trophic ulcers of the lower leg are late indicators of chronic venous insufficiency (CVI). The presence of a venous trophic ulcer of the leg is a disabling condition that is widespread among the elderly. The study included 98 patients aged 20 to 78 years with chronic venous insufficiency, including, in accordance with the CEAP classification, 45 patients with moderate CVI (class C3-C4) and 53 patients with severe CVI (class C5-C6). The results obtained in the course of the study indicate that the G4682A polymorphism of the TNF-α gene is significantly important in the development of complicated forms of CVI.

Keywords: chronic venous insufficiency, venous trophic ulcers, TNF-α polymorphism

First page

134

Last page

138

For citation: Vasilevsky E.A., Aleinik V.A., Musashaikhov Kh.T., Dadabaev O.T. PREVALENCE OF ALLELIC AND GENOTYPICAL VARIANTS OF TNF-Α GENE G4682A POLYMORPHISM IN CHRONIC VENOUS INSUFFICIENCY COMPLICATED BY VENOUS TROPHIC ULCERS //New Day in Medicine 12(50)2022 134-138 https://clck.ru/3379zC

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