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  • 23 -12 (50) 2022 — Dadabaev O.T., Aleinik V.A. — PROGNOSTIC POSSIBILITY OF TUMOR NECROSIS FACTOR ALPHA IN DIABETIC FOOT SYNDROME IN PATIENTS WITH DIABETES MELLITUS

23 -12 (50) 2022 — Dadabaev O.T., Aleinik V.A. — PROGNOSTIC POSSIBILITY OF TUMOR NECROSIS FACTOR ALPHA IN DIABETIC FOOT SYNDROME IN PATIENTS WITH DIABETES MELLITUS

PROGNOSTIC POSSIBILITY OF TUMOR NECROSIS FACTOR ALPHA IN DIABETIC FOOT SYNDROME IN PATIENTS WITH DIABETES MELLITUS

Dadabaev O.T., Andijan State Medical Institute

Aleinik V.A., Andijan State Medical Institute

Musashaikhov Kh.T., Andijan State Medical Institute

Vasilevsky E.A. Andijan State Medical Institute

Resume

Among the various complications associated with type 2 diabetes mellitus, diabetic foot syndrome is a serious and often complex clinical problem. TNF-α is a well-characterized SNP that has previously been associated with various complications of diabetes mellitus. However, the involvement of the TNF-α gene in the pathogenesis of DFS is still poorly understood. The aim of the study was to elucidate the role of the G4682A polymorphism of the TNF-α gene in susceptibility to the occurrence of DFS. The study included 96 patients suffering from SDS. It was found that the risk of the body’s susceptibility to DFS with the carriage of the G/A genotype significantly increases – more than 1.5 times (χ2 = 2.7; p = 0.2; CI 95% 0.87–4.72)

Keywords: diabetic foot syndrome, diabetes mellitus, TNF-α polymorphism

First page

139

Last page

142

For citation: Dadabaev O.T., Aleinik V.A., Musashaikhov Kh.T., Vasilevsky E.A. PROGNOSTIC POSSIBILITY OF TUMOR NECROSIS FACTOR ALPHA IN DIABETIC FOOT SYNDROME IN PATIENTS WITH DIABETES MELLITUS //New Day in Medicine 12(50)2022 139-142 https://clck.ru/337A7u

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