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  • 124 -12 (50) 2022 — F.N. Sabirov,U.U. Jabborov, — FETAL CYTOKINES IN PREGNANT WOMEN WHO HAD COVID-19 IN THE THIRD TRIMESTER OF GESTATION

124 -12 (50) 2022 — F.N. Sabirov,U.U. Jabborov, — FETAL CYTOKINES IN PREGNANT WOMEN WHO HAD COVID-19 IN THE THIRD TRIMESTER OF GESTATION

FETAL CYTOKINES IN PREGNANT WOMEN WHO HAD COVID-19 IN THE THIRD TRIMESTER OF GESTATION

F.N. Sabirov,Republican Perinatal Center of the Ministry of Health of the Republic of Uzbekistan

U.U. Jabborov, Republican Perinatal Center of the Ministry of Health of the Republic of Uzbekistan

A.A. Ismoilova Republican Perinatal Center of the Ministry of Health of the Republic of Uzbekistan

Resume

Objective: the results of a study of 4 main cytokines IL-1ß, IL-18, IL-4 and IL-6 fetuses in pregnant women who underwent COVID-19 with both moderate and severe course of the disease in the third trimester of gestation are presented.

Materials and methods: Immunological studies were carried out on 30 fetal cord blood sera taken by transabdominal cordocentesis in pregnant women with COVID-19 in the third trimester of gestation at the Republican Perinatal Center in 2022. The research was conducted at the Institute of Immunology.

Results: the average content of IL-18, IL-4 and IL-6 in the fetus against the background of a severe course of COVID-19 was significantly increased by 1.5, 1.6 and 2 times, and the content of IL-1β in the fetus against the background of experienced severe course of COVID-19 was not significantly increased compared with normative data.

Conclusion: Cytokines act as mediators in the development of immune and inflammatory reactions in the mother-placenta-fetus system, but at the same time they can contribute to the disruption of the functional and morphological properties of cell membranes, deplete the protective reserves of cells.

Keywords: COVID-19, cytokines, IL-1ß, IL-18, IL-4, IL-6, III-trimester of pregnancy.

First page

721

Last page

725

For citation: F.N. Sabirov,U.U. Jabborov, A.A. Ismoilova – FETAL CYTOKINES IN PREGNANT WOMEN WHO HAD COVID-19 IN THE THIRD TRIMESTER OF GESTATION //New Day in Medicine 12(50)2022 721-725 https://clck.ru/33HRFz

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