5 -1 (51) 2023 — Xamraev O.A., Israilov R.I. — MECHANISM OF SCLEROSIS AND PATHOMORPHOLOGY OF THE STROMA OF THE MIDDLE LOBES OF THE PROSTATE GLAND

MECHANISM OF SCLEROSIS AND PATHOMORPHOLOGY OF THE STROMA OF THE MIDDLE LOBES OF THE PROSTATE GLAND

Xamraev O.A., Andijan State Medical Institute. Uzbekistan.

Israilov R.I., Republican Center of Pathological Anatomy. Tashkent. Uzbekistan.

Kosimhojiev M.I. Andijan State Medical Institute. Uzbekistan.

Resume

In this study, pathomorphological changes were studied that develop as a result of chronic inflammation in the interstitial tissue of the glandular region around the urethra from various topographic regions of the prostate gland.  At autopsy of the RPAC, the middle lobe of the prostate gland was removed from the corpses of men and examined histologically. The results obtained show that the development of fibromatosis in the periurethral region of the prostate gland is characterized by pathomorphological changes characteristic of long-term chronic inflammation, i.e., first the appearance of a lymphohistiocytic infiltrate, then the proliferation of connective tissue occurs with an increase in the proliferative activity of histiocytic cells. At the same time, differentiated fibroblasts, underdeveloped fibroblasts, differentiated fibroblasts and myofibrocytes multiply and turn into fibroblasts, which synthesize a large amount of collagen and form fibrous tissue. In some cases, myxomatosis of fibromatous tissue is due to a large accumulation of acidic glycamingglycans from 2 types of polysaccharides in the intermediate substance, the acidic environment and hydrophilicity of the tissue increase, the acidic dye eosin is less absorbed, and basophilic staining is observed.

Key words: prostate, middle lobe, prostatitis, sclerosis, fibrosis, morphogenesis, pathomorphology.

First page

20

Last page

24

For citation: Xamraev O.A., Israilov R.I., Kosimhojiev M.I. – MECHANISM OF SCLEROSIS AND PATHOMORPHOLOGY OF THE STROMA OF THE MIDDLE LOBES OF THE PROSTATE GLAND //New Day in Medicine 1(51)2023 20-24 https://clck.ru/33Jhpb

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