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  • 1 -2 (52) 2023 — F.N. Sabirov, U.U. Jabborov, — FETAL CYTOKINES IN PREGNANT WOMEN WHO HAD COVID-19 IN THE THIRD TRIMESTER OF GESTATION

1 -2 (52) 2023 — F.N. Sabirov, U.U. Jabborov, — FETAL CYTOKINES IN PREGNANT WOMEN WHO HAD COVID-19 IN THE THIRD TRIMESTER OF GESTATION

FETAL CYTOKINES IN PREGNANT WOMEN WHO HAD COVID-19 IN THE THIRD TRIMESTER OF GESTATION

F.N. Sabirov, Bukhara State Medical Institute Republican Perinatal Center of the Ministry of Health of the Republic of Uzbekistan

U.U. Jabborov, Bukhara State Medical Institute Republican Perinatal Center of the Ministry of Health of the Republic of Uzbekistan

N.A. Urinbaeva Bukhara State Medical Institute Republican Perinatal Center of the Ministry of Health of the Republic of Uzbekistan

Resume

Immunological study of the 4 main cytokines IL-1ß, IL-18, IL-4 and IL-6 fetuses in pregnant women who underwent COVID-19 with both moderate and severe course of the disease in the III trimester of gestation. The average content of IL-18, IL-4 and IL-6 in the fetus against the background of severe COVID-19 was significantly increased by 1.5, 1.6 and 2 times, and the content of IL-1ß in the fetus against the background of severe COVID-19 was not significantly increased compared to the normative data. Cytokines act as intermediaries in the development of immune and inflammatory reactions in the mother-placenta-fetus system, but at the same time they can contribute to the violation of the functional and morphological properties of cell membranes, deplete the protective reserves of cells.

Keywords: COVID-19, cytokines, IL-1ß, IL-18, IL-4, IL-6, III-trimester of pregnancy.

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For citation: F.N. Sabirov, U.U. Jabborov, N.A. Urinbaeva – FETAL CYTOKINES IN PREGNANT WOMEN WHO HAD COVID-19 IN THE THIRD TRIMESTER OF GESTATION //New Day in Medicine 2 (52) 2023 2-6 https://clck.ru/33UnSF

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