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  • 36 -2 (52) 2023 — Turaeva N.O., Mamatkulova D.H. — CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF BRONCHOBSTRUCTIVE SYNDROME IN CHILDREN

36 -2 (52) 2023 — Turaeva N.O., Mamatkulova D.H. — CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF BRONCHOBSTRUCTIVE SYNDROME IN CHILDREN

CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF BRONCHOBSTRUCTIVE SYNDROME IN CHILDREN

Turaeva N.O., Samarkand State Medical University, Uzbekistan

Mamatkulova D.H. Samarkand State Medical University, Uzbekistan

Resume

The pathology of the respiratory organs in young children remains one of the urgent problems of modern pediatrics.

The aim of the study was to study the clinical and immunological characteristics of broncho-obstructive syndrome in children. The study involved 86 patients aged 3 to 15 years with acute obstructive bronchitis, recurrent obstructive bronchitis and bronchial asthma.

The results of the study showed that vitamin D deficiency was accompanied by the development of secondary immune deficiency.

Thus, in broncho-obstructive syndrome, depending on the underlying disease, the level of blood serum cytokines changes, which is characterized by a significant increase in such cytokines as IL-4, IL-8, TNFα and a decrease in IFNγ. The increase in the severity of broncho-obstructive syndrome is directly proportional to the decrease in the level of vitamin D metabolites in the blood serum, which is clearly manifested in children with bronchial asthma.

Key words: broncho-obstructive syndrome, vitamin D, immune status, children.

First page

215

Last page

220

For citation: Turaeva N.O., Mamatkulova D.H. – CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF BRONCHOBSTRUCTIVE SYNDROME IN CHILDREN //New Day in Medicine 2(52)2023 215-220 https://clck.ru/33dBG6

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