• Home
  • NEW DAY MEDICINE
  • 2 (52) 2023
  • 44 -2 (52) 2023 — Khamraev Uktam Pirnazarovich, Khamdamov Bakhtiyor Zarifovich — FEATURES OF CHANGES IN THE INDICATORS OF THE ENDOTHELIAL SYSTEM IN PATIENTS WITH DIFFUSE TOXIC GOITER

44 -2 (52) 2023 — Khamraev Uktam Pirnazarovich, Khamdamov Bakhtiyor Zarifovich — FEATURES OF CHANGES IN THE INDICATORS OF THE ENDOTHELIAL SYSTEM IN PATIENTS WITH DIFFUSE TOXIC GOITER

FEATURES OF CHANGES IN THE INDICATORS OF THE ENDOTHELIAL SYSTEM IN PATIENTS WITH DIFFUSE TOXIC GOITER

Khamraev Uktam Pirnazarovich, Bukhara State Medical Institute, Uzbekistan

Khamdamov Bakhtiyor Zarifovich  Bukhara State Medical Institute, Uzbekistan

Resume

It was revealed that the average data on the activity of enzymes of the endothelial system in the course of research were represented by multipolar values, which in the dynamics of the postoperative period changed their character of significance with an approach to normal values only on the 7th day after surgery. The nature of changes in the content of various substrates of the metabolism of nitroxidergic homeostasis showed heterogeneity of changes. Compensatory changes aimed at utilization of products of the nitroxidergic regulation system, as our observations showed, had a differentiated character. Prolongation of the terms of conservative therapy of diffuse toxic goiter contributes to the inhibition of changes in this functional activity. The deviation in the physiological parameters in the endothelial system, which we found in the dynamics after surgery, in our opinion is of a natural nature.

Key words: diffusely toxic goiter, endothelial system, homeostasis.

First page

263

Last page

269

For citation: Khamraev Uktam Pirnazarovich, Khamdamov Bakhtiyor Zarifovich – FEATURES OF CHANGES IN THE INDICATORS OF THE ENDOTHELIAL SYSTEM IN PATIENTS WITH DIFFUSE TOXIC GOITER //New Day in Medicine 2(52)2023 263-269 https://clck.ru/33dcjQ

LIST OF REFERENCES:

  1. Хамдамов Б.З., Хамроев У.П., Хамдамов А.Б. Характеристика перекисного окисления липидов и антиоксидантной системы у больных  диффузно токсическим зобом  на фоне коррегирующий терапии // Проблемы биологии и медицины. – Самарканд, 2022; 3(136):118-123. 
  2. Хамдамов Б.З., Хамроев У.П., Хамдамов И.Б. Assesment of efficiency of surgical treatment of the diffusion toxic craw  // Europe’s Journal of  Psychology 2021; 123-127.
  3. Okhunov AO, Sayfullaeva S. Activity of monooxygenase and nitrogenous systems in liver microsomes under the influence of inducers and inhibitors of medicinal metabolism on the organism in conditions of liver pathology //International Journal of Psychosocial Rehabilitation 2020; 24:416-421
  4. Atakov S., Bobokulova S., Kasimov U., Bobabekov A., Okhunov A. Difficult aspects of treatments patients with acute lung abscesses who survived COVID -19. Journal of education and scientific medicine 2022; (1):57-60. Retrieved from https://journals.tma.uz/index.php/jesm/article/view/292
  5. Dora SV, Rybakova MG, Alekseev DA, Krylova YS, Volkova AR, Belyakova LA. Molekuliarno-biologicheskie markery proliferatsii, apoptoza i angiogeneza pri diffuznom toksicheskom zobe [Molecular biological markers for proliferation, apoptosis, and angiogenesis in diffuse toxic goiter]. Arkh Patol. 2017; 79(6):3-7. doi:10.17116/patol20177963-7. PMID: 29265071.
  6. Khamdamov S., Okhunov A. Immediate results of endovascular and little invasive methods of treatment of lung purulent diseases with diabetes mellitus. Journal of education and scientific medicine, 2022; (2):63-65. Retrieved from https://journals.tma.uz/index.php/jesm/article/view/274
  7. Khamdamov B.Z. Indicators of immunocitocine status in purulent-necrotic lesions of the lover extremities in patients with diabetes mellitus //American Journal of Medicine and Medical Sciences. 2020; 10(7):473-478.
  8. Knobel M. Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters. J Endocrinol Invest. 2016; 39(4):357-73. doi:10.1007/s40618-015-0391-7. Epub 2015 Sep 21. PMID: 26392367.
  9. Lavruk KZ, Dudiy PF, Skrypnyk NV, Mishchuk VH, Vytvytskiy ZY. Clinical-laboratory and ultrasound parallels of changes in the liver and thyroid gland in diffuse toxic goiter. J Med Life. 2022 Jan;15(1):78-88. doi: 10.25122/jml-2021-0291. PMID: 35186140; PMCID: PMC8852630.
  10. Modern principals of antibacterial therapy of suppurative-septic diseases | Sovremennye printsipy antibakterial’noi terapii gnoino-septicheskikh zabolevanii / Okhunov, A.O., Babadzhanov, B.D., Kasymov, U.K., Rakhmatov, A.N., ukhitdinov, U.M. // Likars’ka sprava / Ministerstvo okhorony zdorov’ia Ukraïny 2003; (7):70-73.
  11. Okhunov A., Israilov R., Razzakov S., Azizova P., Mominov A. Morphological characteristics of intestinal vessels of animals with an experimental model of diabetes mellitus type 2 complicated by microangiopathy // Indian Journal of Forensic Medicine and Toxicology 2020; 14(4):7348–7353.
  12. Okhunov AO. Morphological characteristics of results of treatment of diabetic angiopathyс // International journal of diabetes and metabolic disorders 2020; 4(4):1-3.
  13. Musiienko V, Sverstiuk A, Lepyavko A, Mazur L, Danchak S, Lisnianska N. Prediction factors for the risk of diffuse non-toxic goiter development in type 2 diabetic patients. Pol Merkur Lekarski. 2022 Apr19; 50(296):94-98. PMID: 35436270.
  14. Okhunov AO. Pathophysiological transformations in the endothelial system under different types of nephropathies // XXXIX International Scientific and Practical Conference European Research: Innovation in Science, Education and Technolog – 2018; 4:3.
  15. Rossato M, Burei M, Vettor R. Neck thermography in the differentiation between diffuse toxic goiter during methimazole treatment and normal thyroid. Endocrine. 2015 Apr; 48(3):1016-7. doi: 10.1007/s12020-014-0305-z. Epub 2014 Jun 5. PMID: 24898902.
  16. Okhunov A.O., Kasymov A.K. Some pathogenic aspects of changes in non-respiratory function of the lungs in sepsis // Likars’ka sprava / Ministerstvo okhorony zdorov’ia Ukraïny, 2006; (7):45-47.
  17. Karimov K.I., Babadzhanov B.D., Okhunov A.O., …Rakhmatov A.N., Kutlimuratov K. Surgical aspects of non-respiratory activity of the lungs during acute pyonecrotizing diseases Khirurgicheskie aspekty nerespiratornoǐ deiatel’nosti legkikh pri ikh ostrykh gnoǐno-destruktivnykh zabolevaniiakh // Likars’ka sprava / Ministerstvo okhorony zdorov’ia Ukraïny, 2004; (1):38-40.
  18. Okhunov AO. The choice of method of surgical correction of complicated forms of diabetes type 2 // International journal of diabetes and metabolic disorders 2020; 4(4):1-3.
  19. Okhunov A.O., Israilov R.I., Khamdamov S.A., Azizova P.X., Anvarov K.D. Treatment of acute lung abscesses considering their non-respiratory function in patients with diabetes // Indian Journal of Forensic Medicine and Toxicology, 2020;14(4):7465–7469.
  20. Vachev AN, Frolova EV, Sakhipov DR, Morkovskikh NV. Vybor ob”ema operatsii u bol’nykh diffuznym toksicheskim zobom (s kommentariem) [The choice of surgery in patients with diffuse toxic goiter]. Khirurgiia (Mosk). 2016; (8):13-17. Russian. doi:10.17116/hirurgia2016813-17. PMID: 27628225.

file

download