43 -3 (53) 2023 — Bahronov J.J. — MORPHOLOGICAL CHANGES IN THE KIDNEYS DURING CHEMOTHERAPY

MORPHOLOGICAL CHANGES IN THE KIDNEYS DURING CHEMOTHERAPY

Bahronov J.J. Bukhara State Medical Institute named after Abu Ali ibn Sino, Uzbekistan

Resume

Kidney damage is a common and serious complication of cancer and anticancer therapy. Its spectrum is very broad and causes damage to the glomeruli, affecting the renal tissue. In addition, the risks associated with complications after bone marrow transplantation (BMT), infections (including sepsis) due to immunosuppression, and tumor lysis syndrome should be considered. Chemotherapy drugs often lead to the development of acute kidney injury. This article discusses the risk factors for kidney damage in cancer patients. They are divided into two groups. General, systemic ones include infiltration of the kidney tissue with tumor cells, dysproteinemia and electrolyte disturbances, as well as a decrease in circulating blood volume. Local (renal) risk factors include microcirculation disorders, drug biotransformation, a high concentration of nephrotoxic substances in the proximal tubules, and the latter’s sensitivity to ischemia. The need for long-term use of high doses of a combination of cytostatics is manifested by the formation of intratubular deposits due to a direct cytotoxic effect and poor solubility of not only chemotherapeutic agents, but also their metabolites. Early diagnosis, timely prevention and treatment of these complications significantly improve non-oncological outcomes of patients’ treatment.

Key words: cancer, nephron, proximal convoluted tubules, distal convoluted tubules, chemotherapy.

First page

241

Last page

245

For citation: Bahronov J.J. – MORPHOLOGICAL CHANGES IN THE KIDNEYS DURING CHEMOTHERAPY //New Day in Medicine 3(53)2023 241-243 https://goo.su/kzWdzTK

LIST OF REFERENCES:

  1. Бахронов Ж.Ж., Тешаев Ш.Ж. Морфометрическая характеристика частей нефрона почек крыс в норме и при воздействии антисептика – стимулятора дорогова фракции 2 на фоне хронической лучевой болезни // Проблемы биологии и медицины. – Самарканд, 2020:4(120):138-140. (14.00.00; № 19).
  2. Богомолова И.Н. Поражения почек при смертельных отравлениях. Всероссийский съезд судебных медиков, 7-й: Труды. М 2013;1-2:187-188.
  3. Гольдман Л.Н., Леонтьев И.А. К вопросу о механизме нарушения функции почек при паренхиматозных гепатитах // Казанский медицинский журнал. 2021;36(4):28-34. doi: 10.17816/kazmj57500.
  4. Медведь В.И. Грицай И. Нарушение функций печени у беременных: Влияние на течение беременности, состояние плода и исход родов // Здоровье Украины. 2015;Спец.Вып:24-27.
  5. Bakhronov J.J and Rakhimova G.Sh., Morphometric changes of kidneys in juvenile white rats // European Journal of Pharmaceutical and Medical Research, 2020;7(6):204-207. www.ejpmr.com. (SJIF Impact Factor 6,222).
  6. Lu L.L, Chen B.X. Maternal transmission risk and antibody levels against hepatitis B virus e antigen in pregnant women // Int J Infect Dis, 2014 Nov;28:41-4.
  7. Medved V.I. Gritsay I. Narushenie funktsiy pecheni u beremennyih: Vliyanie na techenie beremennosti, sostoyanie ploda i ishodov rodov /Zdorovie Ukrainyi. 2015 Spets. Vyip; 24-27.
  8. Julsgaard M. Christensen L.A; Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection. //Gastroenterology. 2016 Jul;151(1):110-9.
  9. Jur’at J. Bakhronov, Shukhrat J. Teshaev, Musharraf S. Shodieva. Morphometric  characteristics  of  parts  of  rat  kidney nephron  in  normal  and  under  the  influence  of  an antiseptician  –  facility  2  roadtimulator  on  the background of chronic radiating disease. International Journal of Pharmaceutical Research, 2021;13(1):683-686 (Scopus)
  10. Givens ML, Wethern J. Renal Complications in Oncologic Patients. Emerg Med Clin North Am 2009;27:283-291. https://doi.org/10.1016/j.emc.2009.01.001
  11. Wilson FP, Berns JS. Tumor Lysis Syndrome: New Challenges and Recent Advances. Adv Chronic Kidney Dis 2014;21(1):16-26. https://doi.org/10.1053/j.ackd.2013.07.001
  12. Luciano RL, Brewster UC. Kidney Involvement in Leukemia and Lymphoma. Adv Chronic Kidney Dis 2014;21(1):27-35. https://doi.org/10.1053/j.ackd.2013.07.004
  13. Jhaveri KD, Shah HH, Patel C et al. Glomerular Diseases Associated With Cancer, Chemotherapy, and Hematopoietic Stem Cell Transplantation. / Adv Chronic Kidney Dis 2014;21(1):48-55. https://doi.org/10.1053/j.ackd.2013.08.003
  14. Perazella MA, Berns JS, Rosner MH. Cancer and the Kidney: The Growth of Onco- nephrology. / Adv Chronic Kidney Dis 2014;21(1):4-6. https://doi.org/10.1053/j.ackd.2013.09.002
  15. Корман ДБ. Основы противоопухолевой химиотерапии. Практическая медицина, М., 2006; 518; [Korman DB. Fundamentals of antitumor chemotherapy. Practical medicine, M., 2006; 518]
  16. Shirali AC, Perazella MA. Tubulointerstitial Injury Associated With Chemotherapeutic Agents. Adv Chronic Kidney Dis 2014;21(1):56-63. https://doi.org/10.1053/j.ackd.2013.06.010
  17. Akilesh S, Juaire N, Duffield JS. et al Chronic Ifosfamide Toxicity: Kidney Pathology and Pathophysiology. //Am J Kidney Dis 2014;63(5):843-850.  https://doi.org/10.1053/j.ajkd.2013.11.028
  18. Campbell GA, Hu D, Okusa MD. Acute Kidney Injury in the Cancer Patient. / Adv Chronic Kidney Dis 2014;21(1):64-71. https://doi.org/10.1053/j.ackd.2013.08.002
  19. Lameire N. Nephrotoxicity of recent anti-cancer agents. // Clin Kidney J 2014;7:11-12. https://doi.org/10.1093/ckj/sft135

file

download