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  • 43 -4 (54) 2023 — Mirzaxodzaxeva D.B., Mavlyanova N.N. — TO THE RESULTS OF THE ANALYSIS OF THE ASSOCIATION POLYMORPHISM OF ALLELIC VARIANTS AND GENOTYPES OF THE ADRB3 GENE FOR THE RISK OF MISCARRIAGE

43 -4 (54) 2023 — Mirzaxodzaxeva D.B., Mavlyanova N.N. — TO THE RESULTS OF THE ANALYSIS OF THE ASSOCIATION POLYMORPHISM OF ALLELIC VARIANTS AND GENOTYPES OF THE ADRB3 GENE FOR THE RISK OF MISCARRIAGE

TO THE RESULTS OF THE ANALYSIS OF THE ASSOCIATION POLYMORPHISM OF ALLELIC VARIANTS AND GENOTYPES OF THE ADRB3 GENE FOR THE RISK OF MISCARRIAGE

Mirzaxodzaxeva D.B., Republican Specialized Scientific and Practical Medical Center for Obstetrics and Gynecology, Tashkent

Mavlyanova N.N., Republican Specialized Scientific and Practical Medical Center for Obstetrics and Gynecology, Tashkent

Dauletova M.J. Republican Specialized Scientific and Practical Medical Center for Obstetrics and Gynecology, Tashkent

Resume

The study involved pregnants women aged 20 to 40 years who were under the supervision of an obstetrician-gynecologist on an outpatient and inpatient basis. All pregnant women underwent clinical, functional, molecular genetic studies. The results of molecular genetic studies have shown that the unfavorable variant allele “C” of the rs4994 polymorphism of the ADRB3 gene, leading to the replacement of T with C, is possibly related to the development of miscarriage in pregnant women. It was found that the risk of developing HB anomalies in pregnant women in the presence of a variant allele of polymorphism in the genome increased by 1.7 times (OR=1.8).

Key words: miscarriage, prediction, ADRB3 gene, genotypes of the T/C gene, C/C of the ADRB3 gene.

First page

224

Last page

229

For citation: Mirzaxodzaxeva D.B., Mavlyanova N.N., Dauletova M.J. – TO THE RESULTS OF THE ANALYSIS OF THE ASSOCIATION POLYMORPHISM OF ALLELIC VARIANTS AND GENOTYPES OF THE ADRB3 GENE FOR THE RISK OF MISCARRIAGE //New Day in Medicine 4(54)2023 224-229 https://newdaymedicine.com/index.php/2023/04/20/s-2/

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