84 -4 (54) 2023 -Sarkisova L.V. — A BIOCHEMICAL MARKER OF PREMATURE BIRTH

A BIOCHEMICAL MARKER OF PREMATURE BIRTH

Sarkisova L.V.  Bukhara State Medical Institute named after Abu Ali ibn Sina Uzbekistan

Resume

Vitamin D deficiency is a real pandemic in the modern world. Vitamin D deficiency is today a global health problem affecting more than 2.3 billion people worldwide.

It should be recognized that this disorder is of interest to both obstetrician-gynecologists and other specialists, since vitamin D deficiency is associated with oncological, neurological, cardiovascular and autoimmune diseases, as well as various pathologies in the field of obstetrics and gynecology. Recently, there has been a sharp increase in interest in the “hormone D” – calcitriol and its receptors (VDR) as risk factors for the development of a number of obstetric complications. Vitamin D receptors have been found in the ovaries, uterus, placenta, and pituitary gland. According to some studies, vitamin D deficiency during pregnancy increases the risk of preterm birth. It is involved in the processes of angiogenesis, inhibition of cell proliferation, maintains genetic homeostasis and final differentiation of fetuses, affects the production of macrophages, the functioning of the pancreas, and the reninangiotensin system.

Key words: vitamin D deficiency, 25-hydroxyvitamin D, general risk groups, pregnancy, preterm birth.

First page

460

Last page

464

For citation: Sarkisova L.V. – A BIOCHEMICAL MARKER OF PREMATURE BIRTH //New Day in Medicine 2023 4(54): 460-464 https://newdaymedicine.com/index.php/2023/04/25/s-37/

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