89 -4 (54) 2023 — Mirzaeva D.B., Saijalilova D.Dj. — FEATURES OF THE DISTRIBUTION OF ALLELE AND GENOTYPE FREQUENCIES OF THE PROGESTERONE RECEPTOR GENE (PRG) IN WOMEN WITH IVF IN THE UZBEK POPULATION

FEATURES OF THE DISTRIBUTION OF ALLELE AND GENOTYPE FREQUENCIES OF THE PROGESTERONE RECEPTOR GENE (PRG) IN WOMEN WITH IVF IN THE UZBEK POPULATION

Mirzaeva D.B., Tashkent Medical Academy

Saijalilova D.Dj. Tashkent Medical Academy

Resume

The distribution of frequencies of alleles and genotypes of the progesterone receptor gene (PRG) in women with in vitro fertilization of the Uzbek population was assessed. A molecular genetic analysis of the blood of 96 women was studied, of which the main group consisted of 82 women with IVF and 14 pregnant women with a physiological course of pregnancy. The mutant allele T was found 3,8 times more often in the group of women with IVF, while in the control group it was found only in 1% of women. The frequency of occurrence of the mutant allele T in the form of a heterozygous G/T genotype and a homozygous T/T genotype in women with infertility showed its highest values in the IVF group, 5,2 times more than in women in the control group. In the control group, the G/T genotype was 2,1%, while the T/T mutant genotype was not detected. Thus, in women of the Uzbek population with IVF, the homozygous genotype T/T of the progesterone receptor gene is found than in women in the control group.

Keywords: in vitro fertilization, receptors, polymorphism, alleles, population.

First page

483

Last page

485

For citation: Mirzaeva D.B., Saijalilova D.Dj. – FEATURES OF THE DISTRIBUTION OF ALLELE AND GENOTYPE FREQUENCIES OF THE PROGESTERONE RECEPTOR GENE (PRG) IN WOMEN WITH IVF IN THE UZBEK POPULATION //New Day in Medicien 4(54)2023 483-485 https://newdaymedicine.com/index.php/2023/04/25/l/

LIST OF REFERENCES:

1. . National Summary Report 2015 // Atlanta Centres for Disease control and prevention 2017;4-10.
2. Chen H., Luo L., Wen Y., He B., Ling H., Shui J., et al. Chlamydia trachomatis and human papillomavirus infection in women from southern Hunan Province in China: a large observational study // Front Microbiol. 2020;11:827.
3. Mirzayeva D.B. Features of the course of pregnancy and childbirth after in vitro fertilization (IVF), taking into account the factor of infertility // Journal of education and scientific medicine. 2023;1(1):12-17.
4. Practice Committee of the American Society for Reproductive Medicine; Practice Committee of the Society for Assisted Reproductive Technology; Practice Committee of the Society of Reproductive Biologists and Technologists. Electronic address: asrm@asrm.org. Minimum standards for practices offering assisted reproductive technologies: a committee opinion // Fertil Steril. 2020 Mar;113(3):536-541. 
5. Saidjalilova D.D., Mirzayeva D.B., Eshtimirova H.A. Ekstrakorporal urug‘lantirishi (EKU) mavjud homilador ayollarda homilani ko‘tara olmaslik va trofoblastik ß-glikoprotein darajasi o ‘rtasidagi aloqa // Dermatovenerologiya va reproduktiv salomatlik yangiliklari. 2022;3-4:88-90.
6. B.G., Buchanan A., Chambers G.M., Kolibiana-kis E.M., Bosdou J. et al. Are singleton pregnancies after assisted reproduction technology (ART) associated with a higher risk of placental anomalies compared with non-ART singleton pregnancies? A systematic review and metaanalysis. // BJOG. 2018.