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  • 104 -4 (54) 2023 — Nabieva N.A. — STUDYING THE CONTRIBUTION OF THE MTHFR (C677T) POLYMORPHIC GENE TO THE DEVELOPMENT MECHANISMS OF INFANTRY CEREBRAL PALSY

104 -4 (54) 2023 — Nabieva N.A. — STUDYING THE CONTRIBUTION OF THE MTHFR (C677T) POLYMORPHIC GENE TO THE DEVELOPMENT MECHANISMS OF INFANTRY CEREBRAL PALSY

STUDYING THE CONTRIBUTION OF THE MTHFR (C677T) POLYMORPHIC GENE TO THE DEVELOPMENT MECHANISMS OF INFANTRY CEREBRAL PALSY

Nabieva N.A. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The features of the distribution of the genetic polymorphism MTHFR (C677T) in children with cerebral palsy (n=100) and its contribution to the mechanisms of development of this pathology were studied. Analyzing the results of studying the features of the distribution of the MTHFR (C677T) genetic polymorphism, taking into account the odds ratio (OR) calculated by us, the presence of minor unfavorable alleles and genotypes of the polymorphic MTHFR gene (C677T) in groups of patients with cerebral palsy and healthy people, a statistically significant association of minor alleles was found T and T/T genotype with an increased risk of developing cerebral palsy in combination with symptomatic epilepsy (SE) by 2.3 (χ2=4.8; P=0.05) and 5.2 times (χ2=6.2; P=0.03).

The results of the study prove the association of unfavorable T allele and T/T genotype of the polymorphic MTHFR gene (C677T) with an increased risk of developing cerebral palsy in combination with SE, which allows them to be considered as independent genetic markers involved in the pathogenetic mechanisms of the formation of an increased risk of this complicated form of cerebral palsy.

Key words: MTHFR gene polymorphism (C677T), allele, genotype, risk of development, cerebral palsy, symptomatic epilepsy.

First page

560

Last page

564

For citation: Nabieva N.A. – STUDYING THE CONTRIBUTION OF THE MTHFR (C677T) POLYMORPHIC GENE TO THE DEVELOPMENT MECHANISMS OF INFANTRY CEREBRAL PALSY //New Day in Medicine 4(54)2023 560-564 https://newdaymedicine.com/index.php/2023/04/30/l-16/

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