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  • 122 -4 (54) 2023 — Sharipova O.A., Bobomuratov T.A. — IMMUNE AND HORMONAL STATUS IN CHILDREN WITH RECURRENT BRONCHITIS ON THE BACKGROUND OF LYMPHATIC DIATHESIS

122 -4 (54) 2023 — Sharipova O.A., Bobomuratov T.A. — IMMUNE AND HORMONAL STATUS IN CHILDREN WITH RECURRENT BRONCHITIS ON THE BACKGROUND OF LYMPHATIC DIATHESIS

IMMUNE AND HORMONAL STATUS IN CHILDREN WITH RECURRENT BRONCHITIS ON THE BACKGROUND OF LYMPHATIC DIATHESIS

Sharipova O.A., Samarkand State Medical University

Bobomuratov T.A. Tashkent Medical Academy

Bakhronov Sh.S. Tashkent Medical Academy

Resume

Lymphatic diathesis in children accompanied by thymomegaly is characterized by a decrease in the adaptive capacity of the body, and also contributes to the development of diseases. The state of immunity and hormonal status in children with recurrent bronchitis is a controversial issue. From this point of view, it was interesting to study the state of the immune and hormonal status in children with recurrent bronchitis against the background of lymphatic diathesis.

The aim of the study was to study the state of the immunological status and the functional activity of the somatotropic, adrenocorticotropic function of the pituitary gland and cortisol in children with recurrent bronchitis against the background of lymphatic diathesis.

Materials and methods. The survey included 119 children with RB aged 2 to 7 years. Group I included 62 (52%) patients with RD, group II included 57 (48%) patients with RD against the background of LD. Thymomegaly I degree (CTTI 0.33-0.36) was detected - in 15 (26.3%) patients II (CTTI 0.37-0.42) - at 20(35.1%) and III degree (CTTI 0.43 or more) - in 22(38.6%) sick children. The basal levels of adenocorticotropic (ACTH), somatotropic hormone (STH) and cortisol in the blood serum were determined. And also studied the state of cellular and humoral immunity in children with recurrent bronchitis.

Results. It was revealed that in children with LHD during the period of exacerbation, RB is characterized by a sharp T-lymphocytopenia and their subpopulation, indicating a functional deficiency of the thymus, and is also accompanied by a decrease in B-lymphocytes and a significant decrease in IgM, IgG immunoglobulins and a deep deficiency of IgA, which in turn has high inverse correlation with the degree of thymomegaly. In children with thymomegaly II,III degree, a compensatory increase in cortisol levels (P<0.001) was found, against the background of a significant decrease in ACTH and 2 times higher than the normative data on the level of growth hormone, leading to an increase in immunosuppression in this category of patients.

Key words: recurrent bronchitis, thymomegaly, hormones, immune system.

First page

666

Last page

674

For citation: Sharipova O.A., Bobomuratov T.A., Bakhronov Sh.S. – IMMUNE AND HORMONAL STATUS IN CHILDREN WITH RECURRENT BRONCHITIS ON THE BACKGROUND OF LYMPHATIC DIATHESIS //New Day in Medicne 4(54)2023 666-674 https://newdaymedicine.com/index.php/2023/05/14/l-43/

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