10 -5 (55) 2023 — Ikhtiyarova G.A., Kudratova D.Sh. — MODERN VIEW OF THE RISK OF DEVELO PMENT OF INTRAUTERIN ANOMALIES OF DEVELOPMENT

MODERN VIEW OF THE RISK OF DEVELOPMENT OF INTRAUTERIN ANOMALIES OF DEVELOPMENT

Ikhtiyarova G.A. Tashkent State Dental Institute Uzbekistan

Kudratova D.Sh. Tashkent State Dental Institute Uzbekistan

Resume

We have studied the assessment of the significance of various risk factors for the birth of a child with congenital developmental anomalies in the Bukhara region. A method for the rational formation of risk groups among pregnant women is proposed, which will increase the level of timely diagnosis of congenital malformations and reduce perinatal and infant mortality in the Bukhara region. The risk factors were folate deficiency (24.9%), vitamin D deficiency (9.8%), zinc deficiency (12.9%) and chronic iodine deficiency (7.5%). In the course of the analysis, congenital malformations of the nervous system were revealed (34.03%), the second place was taken by multiple congenital malformations – (19.9%), the third – congenital malformations of the circulatory system (2.27%). To study the frequency and structure of СМ and fetal chromosomal abnormalities detected using prenatal technologies, the study group (n=80) was formed by random sampling (“every third”) of all cases of examination of pregnant women using prenatal diagnostic methods. . In the course of the study, a predominance in the main group of women aged 20-24 years (50.8%) was established. The proportion of women of young and young age (18-24 years) was 2 times higher than in the comparison group (48.6% versus 24.7%, p<0.01), while the proportion of women aged 35 years and older – 4 times lower (7.9% versus 32.5%, p<0.01). Summing up the results of our study, we can conclude that the structure of CM detected perinatally is dominated by CM of the nervous system (34.4%), multiple malformations (19.9%), and congenital malformations of the circulatory system (2.27%). In CM of the nervous system, the highest sensitivity and specificity is the increase in AFP, as well as ultrasound markers detected in the 1st trimester; with multiple CM – a decrease in PAPP and ultrasound markers in the 2nd trimester, with CM of the circulatory system – ultrasound markers detected in the 2nd-3rd trimesters, with chromosomal abnormalities – a change in the level of hCG and ultrasound markers in the 2nd-3rd m trimesters.

Key words: congenital malformations, chromosomal abnormalities, prenatal diagnosis.

First page

60

Last page

65

For citation: Ikhtiyarova G.A., Kudratova D.Sh. – MODERN VIEW OF THE RISK OF DEVELO PMENT OF INTRAUTERIN ANOMALIES OF DEVELOPMENT //New Day in Medicine 5(55)2023 60-65 https://newdaymedicine.com/index.php/2023/05/22/l-45/

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