30 -5 (55) 2023 — K.Sh.Zakhidova, G.N.Rakhimova — FEATURES OF GENE POLYMORPHISM IN WOMEN OF CHILDBEARING AGE WITH POLYCYSTIC OVARIES OF THE UZBEK POPULATION

FEATURES OF GENE POLYMORPHISM IN WOMEN OF CHILDBEARING AGE WITH POLYCYSTIC OVARIES OF THE UZBEK POPULATION

K.Sh.Zakhidova, Center for the development of professional qualifications of medical workers Uzbekistan Tashkent

G.N.Rakhimova Center for the development of professional qualifications of medical workers Uzbekistan Tashkent

Resume

According to various sources, polycystic ovaries among infertile couples varies up to 53%, in married couples this pathology reaches up to 20-22%. Polycystic ovaries in different populations is 5-10%.

The aim of this study was to investigate the association of the peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala polymorphism.

120 women with PCOS, 30 healthy were examined to compare all parameters. The study used PCR to detect the presence of the PPARG Pro12Ala polymorphism, and all women were subjected to anthropometric, biochemical, and metabolic assessments.

PPARG Pro12Ala polymorphism may contribute to the risk of developing PCOS and abnormal metabolic parameters and can be considered as a biomarker for early diagnosis and clinical prediction of metabolic complications.

 Keywords: gene polymorphism, polycystic ovaries, metabolic syndrome

First page

180

Last page

183

For citation: K.Sh.Zakhidova, G.N.Rakhimova – FEATURES OF GENE POLYMORPHISM IN WOMEN OF CHILDBEARING AGE WITH POLYCYSTIC OVARIES OF THE UZBEK POPULATION //New Day in Medicine 2023 5(55): 180-183 https://newdaymedicine.com/index.php/2023/05/24/l-64/

LIST OF REFERENCES:

1. Дамдинова Л.Ф., Лещенко О.Я. Геномная архитектура хромосомных болезней человека 2016г. Обзор литературы. // Бюллетень ВСНЦ СО РАМН, 2016;1:5(111).
2. Дьяконов С.А., Т.М. Долина, Д.Н. Баканова и соавт Некоторые  патогенетические аспекты синдрома поликистозных яичников. 2 Том. Кремлевская медицина. // Клинический вестник. 2017;4(2):100-108.
3. Кашеварова И.Н. и др. Геномная характеристика хромосомных болезней человека // Генетика, 2016;52(5):511-528.
4. Самбялова А.Ю. Молекулярные механизмы функционирования эндометрия у женщин с синдромом поликистозных яичников* // ActA BiomEdicA SciEntificA, 2020;5(6):9-14.
5. Аzziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E at al The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. // Fertil Steril. 2019;91:456-88.
6. Negar S., Farshad Sh, Leila H.PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis Sci Rep.2020 Jul 29;10(1):12764.
7. Duka R. Characteristics of genetic determination of the development of arterial hypertension and metabolic syndrome in patients with morbid. // J/Sciences of Europe 2019;34-41.
8. Apridonidze T., Essah P.A., Luorno M.J., Nestler J.E..  Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome // J. Clin. Endocrinol. Metab. 2005;90(4):1929-35.