• Home
  • NEW DAY MEDICINE
  • 5 (55) 2023
  • 38 -5 (55) 2023 — Ergashova Sh.E., Narimova G.Dj. — COGNITIVE FUNCTIONS DEPENDING ON STAGE AND DURATION OF ILLNESS WITH CUSHING’S SYNDROME

38 -5 (55) 2023 — Ergashova Sh.E., Narimova G.Dj. — COGNITIVE FUNCTIONS DEPENDING ON STAGE AND DURATION OF ILLNESS WITH CUSHING’S SYNDROME

COGNITIVE FUNCTIONS DEPENDING ON STAGE AND DURATION OF ILLNESS WITH CUSHING’S SYNDROME

Ergashova Sh.E., Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y. Kh. Turakulov, Specialized Hospital

Narimova G.Dj., Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y. Kh. Turakulov, Specialized Hospital

Abidova D.Kh. Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y. Kh. Turakulov, Specialized Hospital

Resume

Patients with Cushing’s syndrome (CS) exhibit poor neuropsychological status, including depression, anxiety, and mania, which also affect health-related quality of life (QoL) [3,5,8,19,29]. Recent data indicate that some behavioral dysfunctions observed in the active phase of SC do not completely disappear after correction of hypercortisolism [6,7,10,14,18,23,24,26,28]. In particular, an increased prevalence of affective changes such as anxiety, emotional lability, and apathy has been described in patients with ACTH-dependent KS after an average of 11 years of remission compared not only with healthy subjects, but also with patients treated for non-functioning pituitary macroadenomas [22].

Keywords: Cushing’s syndrome, depression, anxiety, quality of life

First page

225

Last page

234

For citation: Ergashova Sh.E., Narimova G.Dj., Abidova D.Kh. – COGNITIVE FUNCTIONS DEPENDING ON STAGE AND DURATION OF ILLNESS WITH CUSHING’S SYNDROME //New Day in Medicine 2023 5(55): 225-234 https://newdaymedicine.com/index.php/2023/06/05/l-72/

LIST OF REFERENCES:

  1. Andela CD, van der Werff SJA, Pannekoek JN, van den Berg SM, Mejier OC, van Buchem MA, Rombouts SARB, van der Mast RC, Romijn JA, Tiemensma J et al. Smaller grey matter volumes in the anterior cingulate cortex and greater cerebellar volumes in patients with long-term remission of Cushing’s disease: a case-control study. European Journal of Endocrinology 2013 (169):811–819. (doi:10.1530/EJE-13-0471)
  2. Andela CD, van Haalen FM, Ragnarsson O, Papakokkinou E, Johannsson G, Santos A, Webb SM, Biermasz NR, van der Wee NJA & Pereira AM. Cushing’s syndrome causes irreversible effects on the human brain: a systematic review of structural and functional magnetic resonance imaging studies. European Journal of Endocrinology 2015 173R1–R14. (doi:10.1530/EJE-14-1101)
  3. Arnaldi G, Angeli A, Atkinson AB, Bertagna X, Cavagnini F, Chrousos GP, Fava GA, Findling JW, Gaillard RC, Grossman AB et al. Diagnosis and complications of Cushing’s syndrome: a consensus statement. Journal of Clinical Endocrinology and Metabolism 2003 (88):5593–5602. (doi:10.1210/jc.2003-030871)
  4. Crespo I, Granell-Moreno E, Santos A, Valassi E, Vives-Gilabert Y, De Juan-Delago M, Webb SM, Gómez-Ansón B Resmini E. Impaired decision-making and selective cortical frontal thinning in Cushing’s syndrome. Clinical Endocrinology 2014 (81):826-833. (doi:10.1111/cen.12564)
  5. Dorn LD, Burgess ES, Dubbert B, Simpson SE, Friedman T, Kling M et al. Psychopathology in patients with endogenous Cushing’s syndrome:atypical or melancholic features. Clin Endocrinol. 1995 43:433-42. doi: 10.1111/j.1365-2265.1995.tb02614.
  6. Dorn LD, Burgess ES, Friedman TC, Dubbert B, Gold PW & Chrousos GP. The longitudinal course of psychopathology in Cushing’s syndrome after correction of hypercortisolism. Journal of Clinical Endocrinology and Metabolism1997 (82):912-919. (doi:10.1210/jc.82.3.912)
  7. Heald AH, Ghosh S, Bray S, Gibson C, Anderson SG, Buckler H & Fowler HL. Long-term negative impact on quality of life in patients with successfully treated Cushing’s disease. Clinical Endocrinology 2004 (61):458-465. (doi:10.1111/j.1365-2265.2004.02118.x)
  8. Kelly WF, Kelly MJ Faragher B. A prospective study of psychiatric and psychological aspects of Cushing’s syndrome. Clinical Endocrinology 1996 (45):715-720. (doi:10.1046/j.1365-2265.1996.8690878.x)
  9. Keskin FE, Özkaya HM, Ortaç M, Salaba¸s E, Kadioglu A, Kadioglu P. Sexual function in women with Cushing’s syndrome: a controlled study. Turk J Urol. 2018 44:287-93. doi: 10.5152/tud.2018.74240
  10. Lindsay JR, Nansel T, Baid S, Gumowski J., Nieman LK. Longterm impaired quality of life in Cushing’s syndrome despite initial improvement after surgical remission. Journal of Clinical Endocrinology and Metabolism 2006 (91):447-453. (doi:10.1210/jc.2005-1058)
  11. Loosen PT, Chambliss B, DeBold CR, Shelton R, and Orth DN. Psychiatricphenomenology in Cushing ’s disease. Pharmacopsychiatry. 1992 25:192-8. doi: 10.1055/s-2007-1014405
  12. Lynnette K. Nieman M.D., Cushing’s Syndrome: Update on signs, symptoms and biochemical screening; Eur J Endocrinol. 2015 October; 173(4):M33-M38. doi:10.1530/EJE-15-0464
  13. Resmini E, Santos A, Gomez-Anson B, Lopez-Mourelo O, Pires P, Vives-Gilabert Y, Crespo I, Portella MJ, de Juan-Delago M & Webb SM. Hyppocampal dysfunction in cured Cushing’s syndrome patients, detected by 1H-MR spectroscopy. Clinical Endocrinology 2013 (79):700-707. (doi:10.1111/cen.12224)
  14. Santos A, Resmini E, Martínez-Momblán MA, Crespo I, Valassi E, Roset M, Badia X & Webb SM. Psychometric paerformance of the Cushing QoL questionnaire in conditions of real clinical practice. European Journal of Endocrinology 2012 (167):337-342. (doi:10.1530/EJE-12-0325)
  15. Santos A, Resmini E, Crespo I, Pires P, Vives-Gilabert Y, Granell E, et al. Small cerebellar cortex volume in patients with active Cushing’s syndrome. Eur J Endocrinol. 2014 (171):461-9. doi:10.1530/EJE-14-0371
  16. Santos A, Granell E, Gómez-Ansón B, Crespo I, Pires P, Vives-Gilabert Y, et al. Depression and anxiety scores are associated with amygdala volume in Cushing’s syndrome: preliminary study. Biomed Res Int. 2017 (206):19-35. doi: 10.1155/2017/2061935
  17. Santos A, Resmini E, Pascual JC, Crespo I, Webb SM. Psychiatric symptoms in patients with Cushing’s syndrome: prevalence, diagnosis and management. Drugs. 2017 (77):829-42. doi: 10.1007/s40265-017-0735-z
  18. Sonino N, Bonnini S, Fallo F, Boscaro M & Fava GA. Personality Characteristics and quality of life in patients treated for Cushing’s syndrome. Clinical Endocrinology 2006 (64):314-318. doi:10.1111/j.1365-2265.2006.02462.x
  19. Sonino N, Fava GA, Raffi AR, Boscaro M & Fallo F. Clinical correlates of major depression in Cushing’s disease. Pshycopathology 1998 (31):302-306. (doi:10.1159/000029054)
  20. Sonino N, Fava GA. Psychiatric disorders associated with Cushing’s syndrome: epidemiology, pathophysiology and treatment. CNS Drugs. 2001 (15):361-73. doi:10.2165/00023210-200115050-00003

file

download