39 -5 (55) 2023 — Umarova S.S., Muhamadiyeva L.A. — MODERN IDEAS ON THE PATHOGENESIS OF RHEUMATIC FEVER

MODERN IDEAS ON THE PATHOGENESIS OF RHEUMATIC FEVER

Umarova S.S., Samarkand State Medical University Uzbekistan

Muhamadiyeva L.A., Samarkand State Medical University Uzbekistan

Bahronov Sh. S., Samarkand State Medical University Uzbekistan

Ruzmetova S.U., Samarkand State Medical University Uzbekistan

Normahmatov B.B. Samarkand State Medical University Uzbekistan

Resume

 Group A β-hemolytic streptococci cause postinfectious sequelae (including acute rheumatic fever/rheumatic heart disease) associated with the immune response. Acute rheumatic fever and rheumatic heart disease are global problems. The streptococcal response causes autoimmune reactions that target the heart, joints, brain, skin, and subcutaneous tissue. The recently modified Kissel-Jones criteria remain relevant for the diagnosis of the disease with population risk stratification and include subclinical carditis detected by echocardiography as the main criterion. The article examines the connection of molecular mimicry with streptococcus in the pathogenesis of rheumatic fever.

Key words: molecular mimicry, streptococcus, autoimmune reactions.

First page

235

Last page

239

For citation: Umarova S.S., Muhamadiyeva L.A., Bahronov Sh. S., Ruzmetova S.U., Normahmatov B.B. – MODERN IDEAS ON THE PATHOGENESIS OF RHEUMATIC FEVER //New Day in Medicine 2023 5(55): 235-239 https://newdaymedicine.com/index.php/2023/06/05/l-73/

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