71 -5 (55) 2023 — Abdurakhmanov М.М., Latipov I.I. — DYNAMICS OF CYTOKINE PROFILE INDICATORS IN PATIENTS WITH VITILIGO AS A RESULT OF TREATMENT WITH THE DEVELOPED MODIFIED IMMUNOCORRECTIVE COMPLEX THERAPY

DYNAMICS OF CYTOKINE PROFILE INDICATORS IN PATIENTS WITH VITILIGO AS A RESULT OF TREATMENT WITH THE DEVELOPED MODIFIED IMMUNOCORRECTIVE COMPLEX THERAPY

Abdurakhmanov М.М., Bukhara State Medical Institute named after Abu Ali ibn Sina

Latipov I.I. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

For the period from 2020 to 2023, 118 patients (Group I (main group) n=60, Group II (comparison group) n=58) from patients with two clinical forms of vitiligo were examined. The study included patients of both sexes: 66 women and 52 men, aged 18 to 75 years (mean age 38.5 ± 6.8 years). The control group for immunological studies consisted of 20 healthy donors. Determination of the concentration of immunoglobulins in the blood serum of the main three classes A, M and G was carried out by the conventional method of radial immunodiffusion according to Mancini (1963). Participation of the cytokine link of inflammation was assessed according to the content of TNF-α, IL-2, IL-6, IL-8, IL-10 in blood plasma. The mean concentrations of IL-8/IL-10 and TNF-α/IL-10 in Group I were 3.5± 0.4 pg/mL and 1.2± 0.4 pg/mL, respectively, were statistically significantly lower than Groups II (4.1± 0.12 pg/ml and 1.98± 0.4 pg/ml (p<0.05)).

Keywords: vitiligo, immunocorrective complex therapy, excimer laser, UVB therapy

First page

401

Last page

406

For citation: Abdurakhmanov М.М., Latipov I.I. – DYNAMICS OF CYTOKINE PROFILE INDICATORS IN PATIENTS WITH VITILIGO AS A RESULT OF TREATMENT WITH THE DEVELOPED MODIFIED IMMUNOCORRECTIVE COMPLEX THERAPY //New Day in Medicine 2023 5(55)2023: 401-406 https://newdaymedicine.com/index.php/2023/06/12/l-111/

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