10 -6 (56) 2023 — Jarylkasynova G.J., Yuldashova R.U. — STUDY OF THE INFLUENCE OF MDR1 GENE POLYMORPHISM ON THE EFFICIENCY OF FERROTHERAPY IN PATIENTS WITH IRON DEFICIENCY ANEMIA

STUDY OF THE INFLUENCE OF MDR1 GENE POLYMORPHISM ON THE EFFICIENCY OF FERROTHERAPY IN PATIENTS WITH IRON DEFICIENCY ANEMIA

Jarylkasynova G.J. Bukhara State Medical Institute named after Abu Ali ibn Sina

Yuldashova R.U. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Differentiated selection of pancreas, taking into account not only its effectiveness, but also tolerability, as well as the patient’s adherence to ongoing therapy, is an urgent task today. The ultimate goal of such differentiation is the choice of a drug that will have the greatest efficiency. The solution of the tasks is engaged in a special area in medicine – pharmacogenetics

Keywords: anemia, iron preparations, gene, genotype, alleles

First page

57

Last page

63

For citation: Jarylkasynova G.J., Yuldashova R.U. – STUDY OF THE INFLUENCE OF MDR1 GENE POLYMORPHISM ON THE EFFICIENCY OF FERROTHERAPY IN PATIENTS WITH IRON DEFICIENCY ANEMIA //New Day in Medicine 2023 6(56): 57-63 https://newdaymedicine.com/index.php/2023/06/09/l-94/

LIST OF REFERENCES:

1. Bailey R.L., West K.P., Black R.E. The epidemiology of global micronutrient deficiencies. // Ann Nutr Metab. – 2015. – Vol.6. – P. 22-33.
2. Kassebaum N.J., Fleming T.D., Flaxman A., Phillips D.E., Steiner C., Barber R.M. et al. The global burden of anemia. // Hematol Oncol Clin N Am. – 2016. – Vol.30. – P. 247-308.
3. Armstrong G.R., Summerlee A.J. The Etiology, Treatment and Effective Prevention of Iron Deficiency and Iron Deficiency Anemia in Women and Young Children Worldwide: A Review. // Journal of Womens Health Care. – 2015. – Vol.4(01).
4. Johnson-Wimbley T.D., Graham D.Y. Diagnosis and management of iron deficiency anemia in the 21st century. // Therapeutic Advances in Gastroenterology. SAGE Publications. – 2011. – Vol.4(3). – P. 177–184.
5. Ибрагимова Н.З., Сейпенова А.Н., Танбетова З.Ж. Фармакоэкономический анализ терапии железодефицитной анемии у детей в поликлинических условиях. // Медицинский журнал Западного Казахстана. – 2014. – №3(43). – C. 47-50.
6. Frazer D., Anderson G. Iron Imports. Intestinal iron absorption and its regulation. Am. J. Physiol. 2005;289:631-635.Ganz T. Molecular control of iron transport. J. Am. Soc. Nephrol. 2007;18:394-400.
7. Орлов Ю.П., Долгих В.Т. Метаболизм железа в биологических системах (Биохимические, патофизиологические и клинические аспекты). Биомедицинская химия. 2007;53(1):25-38.
8. Dunn L.L., Rahmanto Y.S., Richardson D.R. Iron uptake and metabolism in the new millennium. Trends Cell Biol. 2007;17:93-100.Казюкова Т.В., Левина А.А., Цветаева Н.В. и др. Регуляция метаболизма железа. Педиатрия. 2006; 6:94-98.
9. Shayeghi M., Latunde-Dada G.O., Oakhill J.S. et al. Identification of an intestinal heme transporter. Cell. 2005;122:789-801.
10. Aller S. G., Yu J., Ward A. et al. Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding // Science. — 2009. — Vol. 323, № 5922. — P. 1718–1722.
11. Ambudkar S. V., Kim I. V., Sauna Z. E. The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1) // Eur. J. Farm. Sci. — 2006. — Vol. 27, № 5. — P. 392–400.
12. Chen, J., Chen, L., Mao, N., & Liu, Y. (2012). Association of the MDR1 3435 polymorphism in patients with refractory rheumatoid arthritis in a Chinese population. Rheumatology international, 32(10), 3127-3130.
13. Kopcho N., Chang G., Komives E. A. Dynamics of ABC transporter P­glycoprotein in three conformational states. Sci Rep 2019; 9(1): 1–11, https://doi.org/10.1038/s41598–019–50578–2.
14. Chinn L.W., Kroetz D.L. ABCB1 pharmacogenetics: progress, pitfalls, and promise. Clin Pharmacol Ther 2007; 81(2): 265–269, https://doi.org/10.1038/sj.clpt.6100052.
15. Loo T.W., Bartlett M.C., Clark D. M. Substrate­induced conformational changes in the transmembrane segments of human P­glycoprotein. Direct evidence for the substrate­induced fit mechanism for drug binding. Biol Chem 2003; 278(16): 13603–13606, https://doi.org/10.1074/jbc.c300073200.
16. Zhao Y., Feng L., Liu L., Zhao R. Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition oа multidrug resistance­associated drug transporters. Life Sci 2019;231: 116557, https://doi.org/10.1016/j.lfs.2019.116557.
17. Kadioglu O., Efferth T. A Machine learning­based prediction platform for P­Glycoprotein modulators and its validation by molecular docking. Cells 2019; 8(10): 1286, https://doi.org/10.3390/cells8101286.
18. Kim Y., Chen J. Molecular structure of human P­glycoprotein in the ATP­bound, outward­facing conformation. Science 2018;359(6378): 915–919, https://doi.org/10.1126/science.aar7389.