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  • 3 -2 (34) 2021 — Narzullayev N.U, Rakhmatov A. A. — CYTOCINE PROFILE IN CHILDREN WITH ACUTE INFLAMMATION OF THE MIDDLE EAR ON THE BACK GROUND OF CHRONIC ACTIVE HEPATITIS

3 -2 (34) 2021 — Narzullayev N.U, Rakhmatov A. A. — CYTOCINE PROFILE IN CHILDREN WITH ACUTE INFLAMMATION OF THE MIDDLE EAR ON THE BACK GROUND OF CHRONIC ACTIVE HEPATITIS

CYTOKINE PROFILE IN CHILDREN WITH ACUTE INFLAMMATION OF THE MIDDLE EAR ON THE BACKGROUND OF CHRONIC ACTIVE HEPATITIS

Narzullaev N.U., Buxara State Medical Institute

Rakhmatov A.A. Buxara State Medical Institute

Resume

Purpose of the study-study of the cytokine profile in children with acute otitis media against the background of complex conservative treatment Research materials and methods: We observed 55 children aged 3 to 10 years with acute otitis media. All children underwent a study for the period from 2018 to 2020, of which 35 children with acute inflammation of the middle ear against the background of chronic active hepatitis, which makes up the main group and 20 children with acute inflammation of the middle ear, which makes up the control group. In all sick children, cytokines (to determine the inflammatory processes) (IFNγ, IL-4) were determined in the peripheral blood serum. IFNγ, IL-4 were determined by enzyme immunoassay using test systems “Vector-Best” of the Russian Federation. Results and discussion: The ratio of IFNγ / IL-4 (pro-inflammatory / anti-inflammatory cytokines or Th1 / Th2) in children with acute otitis media was 2.2. In the presence of a pronounced inflammatory process, that is, in children with acute inflammation of the middle ear, this indicator was 0.96. After carrying out immunocorrective treatment using Immun-5, (The drug is a balanced mixture of natural biologically active substances, the action of which is aimed at activating the body’s immune system. The drug increases the body’s resistance in inflammatory diseases. Use 1 capsule 2 times a day for 60 days.The drug manifests its effects, first of all, through the effect on the system of endogenous interferons and on the expression of cytokines functionally coupled with interferons – IL-2, IL-4, IL-6, IL-10 and IL-17). In the examined children with acute inflammation of the middle ear, IFNγ approached the control values, the content of IL-4, and after treatment did not normalize, remaining 5.5 times higher than the control group, the ratio of IFNγ / IL-4, in children with acute inflammation of the middle ear ear against the background of chronic active hepatitis of the main group; after treatment, this indicator decreased to 0.42. Output:Improvement of the clinical condition of children with acute otitis media, along with suppression of the level of the pro-inflammatory cytokine IFNγ, was accompanied by the disappearance of signs of otitis media, improvement of the general condition of children

Key words: acute otitis media, immune system, cytokines.

First page

15

Last page

20

For citation: Narzullaev N.U., Rakhmatov A.A. Cytokine profile in children with acute inflammation of the middle ear on the background of chronic active hepatitis// New Day in Medicine 2(34)2021 15-20 https://cutt.ly/Iveuqqj

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