13 -6 (56) 2023 — Kamalov T.T., Tojiboev S.S. — RISK FACTORS AFFECTING THE DYNAMICS OF PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH AN ACTIVE STAGE IN CHARCOT

RISK FACTORS AFFECTING THE DYNAMICS OF PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH AN ACTIVE STAGE IN CHARCOT

Kamalov T.T., Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y. Kh. Turakulov, Specialized Hospital

Tojiboev S.S. Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y. Kh. Turakulov, Specialized Hospital

Resume

The purpose of the study is to study risk factors affecting the dynamics of treatment of patients with type 2 diabetes mellitus (DM 2) with an active stage of the Charcot foot.

Material and research methods. 35 patients (prospectively) were examined with  DM 2 and    Charcot foot in the active phase in the period 2022 -2023 in the RSNPMCE. The control group amounted to 20 persons with DM 2 without Charcot foot, in compensation sstage.

Research methods included: biochemical, hormonal (insulin, C-peptide, parathormone, vitamin D3, blood osteocalcin) and instrumental: ECG, MRI of foots, ultrasound of the internal organs,  etc.

Research results. The results showed that 77.1% of patients with a history of Charcot arthropathy had problems with the foot that occurred in the foot with arthropathy of Charcot, such as the ulcer of the feet, amputation or surgical intervention, or a combination of the aforementioned problems.

Conclusions. The most frequent place of defeat of the Charcot was the middle department of the foot, followed by the ankle joint, multiple sections, the rear and front parts of the foot.

2. The results showed that 77.1% of patients with a history of Charcot arthropathy were problems with the foot that occurred in the foot with arthropathy of Charcot, such as the ulcer of the feet, amputation or surgical intervention, or a combination of the aforementioned problems.

3. The results of our study show that the interaction and combination of many factors, including the presence of problems with diabetic foot syndrome, chronic diabetes, age > 60 years, the presence of nephropathy and retinopathy, as well as the duration of the disease, increase the risk of Charcot arthropathy.

Keywords: type 2 diabetes mellitus, heart failure, risk factors, Charcot foot.

First page

79

Last page

85

For citation: Kamalov T.T., Tojiboev S.S. – RISK FACTORS AFFECTING THE DYNAMICS OF PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH AN ACTIVE STAGE IN CHARCOT //New Day in Medicine 2023 6(56): 79-85 https://newdaymedicine.com/index.php/2023/06/09/l-97/

LIST OF REFERENCES:

  1. Jeffcoate W, Game F. The Charcot foot reflects a response to injury that is critically distorted by preexisting nerve damage: an imperfect storm. Diabetes Care (2022) 45:1691-1697.
  2. Sanders LJ. The charcot foot: historical perspective 1827-2003. Diabetes Metab Res Rev (2004) 20(Suppl. 1): S4-S8.  
  3. Dhatariya K, Gooday C, Murchison R, et al. Pedal neuroarthropathy in a nondiabetic patient as a result of long-term amiodarone use.  J Foot Ankle Surg (2009) 48:362-364.
  4. Dardari D. An overview of Charcot’s neuroarthropathy. J Clin Transl Endocrinol (2020) 22: 100239100236. 
  5. Lu V, Zhang J, Thahir A, et al. Charcot knee presentation, diagnosis, management a scoping review. Clin Rheumatol (2021) 40: 4445-4456
  6. Phillips S, Williams AL, Peters JR. Neuropathic arthropathy of the spine in diabetes. Diabetes Care (1995) 18:867-869.  
  7. Lambert AP, Close CF. Charcot neuroarthropathy of the wrist in type 1 diabetes. Diabetes Care 2005 28:984-985.  
  8. Wilmot E, Jadoon K, Olczak S. Charcot’s neuroarthropathy of the wrist in type 2 diabetes Charcot’s. Pract Diab Int (2008) 25:263. 
  9. Rastogi A, Prakash M, Bhansali A. Varied presentations and outcomes of Charcot neuroarthropathy in patients with diabetes mellitus.  Int J Diabetes Dev Ctries (2019) 39:513-522. 
  10. Donegan R, Sumpio B, Blume P. Charcot foot and ankle with osteomyelitis.  Diabet Foot Ankle. (2013) 4:213-61. 
  11. Jeffcoate W. Charcot foot syndrome. Diabet Med (2015) 32:760-770. 
  12. Armstrong D, Todd W, Lavery L, et al. The natural history of acute Charcot’s arthropathy in a diabetic foot speciality clinic. Diabetic Medicine (1997) 14:357-363. 
  13. Metcalf L, Musgrove M, Bentley J, et al. Prevalence of active Charcot disease in the East Midlands of England. Diabet Med (2018) 35: 1371-1374. 
  14. Svendsen O, Rabe OO, Winther-Jensen M, et al. How common is the rare charcot foot in patients with diabetes? Diabetes Care (2021) 44: 62-63. 10.2337/dc20-259
  15. Fishco WD. Surgically induced Charcot’s Foot. J Am Podiatr Med Assoc. (2001) 91:388-93. 
  16. Aragón-Sánchez J, Lázaro-Martínez JL, Hernández-Herrero MJ. Triggering mechanisms of neuroarthropathy following conservative surgery for osteomyelitis. Diabetic Med. (2010) 27:844-7.
  17. Keukenkamp R, Busch-Westbroek TE, Barn R, Woodburn J, Bus SA. Foot ulcer recurrence, plantar pressure and footwear adherence in people with diabetes and Charcot midfoot deformity: A cohort analysis. Diabet Med. (2021) Apr 38(4):144-38. doi: 10.1111/dme.14438. Epub (2020) Nov 3. 

file

download