19 -6 (56) 2023 — Mukhamedova Sh.T., Ergasheva M.U. — GENE POLYMORPHISM OF CYTOKINES IN DYSMETABOLIC NEPHROPATHIES

GENE POLYMORPHISM OF CYTOKINES IN DYSMETABOLIC NEPHROPATHIES

Mukhamedova Sh.T., Bukhara State Medical Institute named after Abu Ali ibn Sina

Ergasheva M.U. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The article is devoted to the study of clinical, functional and immunobiochemical indicators of dysmetabolic nephropathy in newborns and their mothers in the periods before and after childbirth, the authors obtained scientifically based results on the determination of risk factors for the development of dysmetabolic nephropathy, developed informative indicators of renal pathology. For the first time, the genetic polymorphism of the C-174G IL-6 gene was studied in children of the Uzbek population living in the conditions of the Bukhara region and it was proved that both healthy and sick children with dysmetabolic nephropathy often carry the G allele of the C-174G polyformism of the IL-6 gene. It has been proven that carriers of the G allele have a C-174G polymorphism of the IL-6 gene 2.57 times more likely to get sick with dysmetabolic nephropathy with the formation of urolithiasis.

Keywords: newborns, dysmetabolic nephropathy, gene polymorphism, cytokines, immunity

First page

115

Last page

120

For citation: Mukhamedova Sh.T., Ergasheva M.U. – GENE POLYMORPHISM OF CYTOKINES IN DYSMETABOLIC NEPHROPATHIES //New Day in Medicine 2023 6(56): 115-120 https://newdaymedicine.com/index.php/2023/06/13/l-133/

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