• Home
  • NEW DAY MEDICINE
  • 6(56)2023
  • 37 -6 (56) 2023 — Rakhmatov A.A., Gaffarova V.F. — IMMUNOLOGICAL FEATURES IN CHILDREN WITH ACUTE MIDDLE EAR INFLAMMATORY ON THE BACKGROUND OF CHRONIC ACTIVE HEPATITIS

37 -6 (56) 2023 — Rakhmatov A.A., Gaffarova V.F. — IMMUNOLOGICAL FEATURES IN CHILDREN WITH ACUTE MIDDLE EAR INFLAMMATORY ON THE BACKGROUND OF CHRONIC ACTIVE HEPATITIS

IMMUNOLOGICAL FEATURES IN CHILDREN WITH ACUTE MIDDLE EAR INFLAMMATORY ON THE BACKGROUND OF CHRONIC ACTIVE HEPATITIS

Rakhmatov A.A., Bukhara State Medical Institute named after Abu Ali ibn Sina

Gaffarova V.F. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Purpose of the study- study of immunological characteristics in children with acute inflammation of the middle ear against the background of complex conservative treatment

Research materials and methods: We observed 55 children aged 3 to 10 years with acute otitis media. All children underwent a study for the period from 2018 to 2020, of which 35 children with acute inflammation of the middle ear against the background of chronic active hepatitis, which makes up the main group and 20 children with acute inflammation of the middle ear, which makes up the control group. In all sick children, cytokines (to determine the inflammatory processes) (IFNγ, IL-4) were determined in the peripheral blood serum. IFNγ, IL-4 were determined by enzyme immunoassay using test systems “Vector-Best” of the Russian Federation.

Results and discussion: The ratio of IFNγ / IL-4 (pro-inflammatory / anti-inflammatory cytokines or Th1 / Th2) in children with acute otitis media was 2.2. In the presence of a pronounced inflammatory process, that is, in children with acute inflammation of the middle ear, this indicator was 0.96. After carrying out immunocorrective treatment using Immun-5, (The drug is a balanced mixture of natural biologically active substances, the action of which is aimed at activating the body’s immune system. The drug increases the body’s resistance in inflammatory diseases. Use 1 capsule 2 times a day for 60 days.The drug manifests its effects, first of all, through the effect on the system of endogenous interferons and on the expression of cytokines functionally coupled with interferons – IL-2, IL-4, IL-6, IL-10 and IL-17). In the examined children with acute inflammation of the middle ear, IFNγ approached the control values, the content of IL-4, and after treatment did not normalize, remaining 5.5 times higher than the control group, the ratio of IFNγ / IL-4, in children with acute inflammation of the middle ear ear against the background of chronic active hepatitis of the main group; after treatment, this indicator decreased to 0.42.

Output: Improvement of the clinical condition of children with acute otitis media, along with suppression of the level of the pro-inflammatory cytokine IFNγ, was accompanied by the disappearance of signs of otitis media, improvement of the general condition of children

Key words: acute otitis media, immune system, cytokines.

First page

227

Last page

231

For citation: Rakhmatov A.A., Gaffarova V.F. – IMMUNOLOGICAL FEATURES IN CHILDREN WITH ACUTE MIDDLE EAR INFLAMMATORY ON THE BACKGROUND OF CHRONIC ACTIVE HEPATITIS //New Day in Medicine 2023 6(56): 227-231 https://newdaymedicine.com/index.php/2023/06/19/l-181/

LIST OF REFERENCES:

  1. Афонькин В.Ю. «Реабилитация слуха у больных острым средним отитом на фоне применения фенсприда». Вестник оториноларингологии. (2018) 1:59-60.
  2. Богомильский М.Р., Палунин М.М., Поляков Д.П. и др. «Состояние слуха у детей, перенесших острый средний отит, с применением парацентеза» Вестник оториноларингологии. (2018) 1:17-20.
  3. Варпаховская И.М. Синдром Приобретенного Иммунодефицита: иммуномодуляторы, вакцины, новые методы лечения Ремедиум. – Москва, (2015) 1:64-68.
  4. Ивашкин В.Т. Особенности иммунного ответа у больных хроническим вирусным гепати­том С В.Т. Ивашкин, С.Н. Мамаев, Е.А. Лукина Российский журнал гастроэнтерологии, гепатологии, колопроктологии,  (2015) XI(3):24-29.
  5. Меркушкина Т.А., Мирахмедова Н.Н., Концентрация цитокинов ИФН-гамма и ИЛ-4 при ВИЧ/ СПИД-заболевании у детей и взрослых Журнал теоретической и клинической медицины. – Ташкент, (2017):163.
  6. Москалева Е.В. Динамика показателей иммунного статуса на фоне коррекции антиретровирусной терапии у детей с перинатальной ВИЧ-инфекцией.  Дни иммунологии в Сибири: матер. всерос. науч.-практ. конф., посвящ. 30-летнему юбилею ГУНИИ мед. проблем Севера СО РАМН и 25-летнему юбилею ГУ НИИ клинический иммунологии СО РАМН. – Красноярск, (2016):140-141.
  7. Москалева Е.В. Изменение показателей интерлейкинового статуса у детей с перинатальной ВИЧ-инфекцией на фоне иммунокоррекции. Вопросы современной педиатрии. (2016) 1:392-393.
  8. Narzullaev N.U. FarGALS efficiency in complex treatment of HIV-infected children with acute purulent sinusitis European Science Review. – Austria, (2017) 1-2:86-88.
  9. Narzullaev N.U. The Incidence of exudative otitis media in HIV-infected children International Journal BIOMEDICINE (IJBM) USA. (2012) 1:211-213.
  10. Narzullaev N.U. Immune Status of HIV-positive Children with Acute Rhinosinusitis. International Journal of Public Health Science (IJPHS) USA. (2020) 2(3):83-88.
  11. Narzullayev N.U., Ikhtiyarova G.A.,Olimova N.I., Clinical and epidemiological characteristics of acute otitis media in hiv-infected children born to hiv- infected mothers New Day in Medicine (2020) 1(29):287-289 https://newdaymedicine.com/index.php/2020/04/09/79-1-29-2-2020
  12. Narzullaev N. U. The clinic-epidemiological characteristic of the sharp average otitis at a hiv-infected of children New Day in Medicine (2019) 2(26):223-225 https://newdaymedicine.com/index.php/2019/07/16/60-2-26-2-2019
  13. Нарзуллаев Н.У. Цитокиновый профиль  детей с острым воспалением среднего уха при  остром  респираторном заболевании на фоне лечения. //Доктор ахборотномаси. №2. Самарканд.  2019г. с.80-83.
  14. Gaffarova V.F. Мethod for prediction of psycho-speech disorders during febril conversions in children. ScienceAsia  (2022) 48:951-955.
  15. Gaffarova V.F. Clinic-eeg correlation somatogenous of conditioned febrile seizures in children. International Journal of Human Computing Studies. (2021):114-116.
  16. Сафаров С.С. Противовирусная иммунокорригирующая терапия при хроническом гепати¬те В у детей. Актуальные вопросы инфекционной патологии и вакцинопрофилактики у детей : матреалы VI конгресса педиатров-инфекционистов России (г. Москва, 13—14 декабря 2017 г.). – М. : ВИССЛА-ПРЕСС, (2017):144-145.

file

download