9 -2 (34) 2021 — Karimova N.K., Nozima, S.S., — FEATURES OF THE COURSE OF METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS IN THE ENDEMIC ZONE OF IODINE DEFICIENCY

FEATURES OF THE COURSE OF METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS IN THE ENDEMIC ZONE OF IODINE DEFICIENCY

Karimova N.K., -Samarkand State Medical Institute

Nozima, S.S., -Samarkand State Medical Institute

Abduraufova N, -Samarkand State Medical Institute

Xusanova S. -Samarkand State Medical Institute

Resume

Relevance. Today metabolic syndrome (MS) can be considered an epidemic – about 25% of the adult population suffers from this disease, with an increasing prevalence among young people. In total, there are more than 310 million people with MS in the world, MS significantly increases the risk of developing CVD (3 times) and the risk of death from them (2 times), and also increases the risk of developing NIDDM (5 times).

Purpose: To study the features of the course of metabolic syndrome in the region of iodine deficiency in adolescent children.

Materials and methods: The objects of the study were patients with metabolic syndrome: 60 patients with adolescents aged 10 to 18 years old, the control group consisted of 30 practically healthy adolescents.

Result: The vast majority of patients with TD had abdominal obesity, arterial hypertension; HDL in patients with disorders of carbohydrate metabolism and hypertriglyceridemia. In group 2 patients, in addition to abdominal obesity, which occurred in 83.3% of cases, in the first place was arterial hypertension; (86.7%). P disorders of carbohydrate metabolism (80.0%) and a decrease in HDL levels (76.7%), (63.3%).

Conclusions: In patients with metabolic syndrome in combination with thyroid dysfunction, multicomponent variants of the metabolic syndrome were more common.

Key words: obesity, insulin resistance, metabolic syndrome, arterial hypertension, body mass index.

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For citation: Karimova N.K., Nozima, S.S., Abduraufova N, Xusanova S. Features of the course of metabolic syndrome in children and adolescents in the endemic zone of iodine deficiency//New Day in Medicine 2(34)2021 https://cutt.ly/LvFpsOU

LIST OF REFERENCES

  1. Almazov V.A., Blagosklonnaya Ya.V., Shlyakhto E.V., Krasilnikova E.I. Metabolic cardiovascular syndrome. – SPb .: SPbGMU, 2010.-202 p.
  2. Fokina A.S., et al. American Diabetes Association. Diabetes from A to Z. The knowledge you need about diabetes – in a simple statement. Per from /English. Ed. A.S. Fokina, A.A. Fokina, L.P. Churilova, Yu.I. Stroeva. – SPb: ElBi, 2013.- 206 p.
  3. Alexandrov O.V., Alekhina R.M., Grigoriev S.P. and other Metabolic syndrome. Ros honey journal 2016; 6: 50-55.
  4. Balabolkin M.I., Mamaeva G.G., Kravchenko T.V. Gene polymorphism in patients with arterial hypertension and non-insulin dependent diabetes mellitus. / Actual problems of modern endocrinology. Mater. IV All-Russia. Congress of Endocrinologists. – SPb, 2011. – P. 19.
  5. Balluzek M.F. Age features of the course, naduvant phototherapy of cardiovascular metabolic syndrome: Author’s abstract. dis. … Cand. honey. Sciences. – SPb., 2012.
  6. Belyakov N.A., Mazurov V.I. Obesity – SPb .: Publishing house SPbMAPO, 2013.
  7. Belyakov N.A., Chubrieva S.Yu., Glukhov N.V., Chubkin I.V. The role of leptin in the pathogenesis of polycystic ovary syndrome and metabolic syndrome in women // Clinical pathophysiology, 2015.-t. 2.-N 1.- e. 73-80.
  8. Blagosklonnaya Ya.V., Krasilnikova E.I., Babenko Yu.A. Obesity and its potential role in the development of metabolic syndrome. // New St. Petersburg Medical Bulletins, – 2010. – No. 4. – P. 43-48.
  9. Blagosklonnaya Ya.V., Shlyakhto EV, Krasilnikova EI. Metabolic cardiovascular syndrome // Russ.med. zhurn. – 2011 – Vol. 9, No. 2.
  10. Blagosklonnaya Ya.V., Krasilnikova E.I., Babenko A.Yu. Obesity and its potential role in the development of metabolic syndrome. Treatment // Medical statements. – 2011. – No. 1 (7).
  11. Blagosklonnaya Ya.V. Obesity and its potential role in the development of metabolic syndrome (Part 11) Ya.V. Blagosklonnaya, E.I. Krasilnikova, E.V. Shlyakhto // Russian medical journal. – 2011. – Vol. 9, No. 2. – S.67-71.
  12. Blagosklonnaya Ya.V. and others. Trunk obesity and insulin resistance is a key link in metabolic cardiovascular syndrome \ Ya.V. Blagosklonnaya, E.I. Krasilnikova, E.V. Shlyakhto // Diabetes mellitus. – 2013. – No. 1 – P.12-15.
  13. Butrova S.A. Metabolic syndrome and the role of abdominal obesity in its development (issues of pathogenesis, manifestations, modern approaches to treatment). / Obesity. Metabolic syndrome. Diabetes mellitus type 2. Ed. Academician of the Russian Academy of Medical Sciences I.I. Dedova. – M., 2010. S. 38-43.
  14. Volkova K.G. Arterial hypertension as a factor that enhances the development of atherosclerosis. / Proceedings of the XIV Vses. Congress of Therapists. – M., 2014. – S. 45-49.
  15. Volkova A.R., Dora S.V., Badmaeva M.I., Dorofeykov V.V., Ivanov V.I., Esipovich I.D., Kozulin V.Yu., Zverev D.A., Grineva E.N., Shlyakhto E.V. The severity of coronary atherosclerosis in patients with ischemic heart disease with various functional states of the thyroid gland // News of Medicine and Pharmacy. – 2010. – 3 (27).
  16. Е.А. Ginsar [et al.] Prevalence and structure of metabolic syndrome in working women in Mirny (Republic of Sakha-Yakutia) / Е.А. Ginsar [et al.] // Disease prevention and health promotion. – 2008. – No. 6.
  17. Gromnatsky N.I., Medvedev I.N., Kondratova I.V. // Russian medical journal. – 2013.- No. 5.- P. 258-262.
  18. Davidenkova E.F., Lieberman I.S., Stroyev Yu.I. and others. Early detection of atherogenic changes in metabolism and preclinical signs of lesions of the cardiovascular system in families of patients with atherosclerosis. / Lipoproteins and atherosclerosis. Abstracts of reports. symposium by eating. 110 th anniversary of the birth. acad. N.N. Anichkova, November 21-23, 2015 – SPb., 2015 .- S. thirty.
  19. Demidova T.Yu., Kruglova E.L. Dynamics of hormonal disorders of a functional nature against the background of pronounced regression of visceral adipose tissue in the treatment of obese patients // RMZh.- 2012. – No. 10,
  20. Deryabina E.G., Thyroid pathology in women after natural and surgical menopause in the iodine-deficient region / E.G. Deryabin. – Author’s abstract. … diss. Dr. med. Science. – M. 2010.- 40s.

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