8 -7 (57) 2023 — Kuryazov A.M.,Alimov T.R. — STUDY OF GENOTYPIC VARIANTS OF THE POLYMORPHIC XENOBIOTIC BIOTRANSFORMATION GENE RS179985 OF THE CYP2C9 GENE IN PATIENTS WITH MYELOPROLIFERATIVE DISEASES

STUDY OF GENOTYPIC VARIANTS OF THE POLYMORPHIC XENOBIOTIC BIOTRANSFORMATION GENE RS179985 OF THE CYP2C9 GENE IN PATIENTS WITH MYELOPROLIFERATIVE DISEASES

Kuryazov A.M., Republican Specialized Scientific and Practical Medical Hematology Center

Alimov T.R., Republican Specialized Scientific and Practical Medical Hematology Center

Mahmudova A.D., Republican Specialized Scientific and Practical Medical Hematology Center

Boboev K.T. Republican Specialized Scientific and Practical Medical Hematology Center

Resume

In this work, we studied the frequency of occurrence, diagnostic value and role of the polymorphic xenobiotic biotransformation gene rs179985 of the CYP2C9 gene in patients with myeloproliferative diseases.

Conducting molecular genetic studies of the rs179985 polymorphism of the CYP2C9 gene in the control group and in the main group showed a moderate excess of heterozygotes in the control group (D* = +0.11) and a slight excess (D* = +0.06) in the main group, which indicates about the low population genetic diversity of this polymorphism in the study group of patients. Therefore, the polymorphism of this gene has no diagnostic and clinical significance in this group of patients.

Key words: myeloproliferative disease, CYP2C9 gene, genotype, polymorphism.

First page

44

Last page

47

For citation: Kuryazov A.M.,Alimov T.R., Mahmudova A.D., Boboev K.T. – STUDY OF GENOTYPIC VARIANTS OF THE POLYMORPHIC XENOBIOTIC BIOTRANSFORMATION GENE RS179985 OF THE CYP2C9 GENE IN PATIENTS WITH MYELOPROLIFERATIVE DISEASES //New Day in Medicine 2023 7(57): 44-47 https://newdaymedicine.com/index.php/2023/07/10/l-252/

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