13 -7 (57) 2023 — Bakoeva N.M. — PREMATURE OVARIAN FAILURE DUE TO COVID-19: IMPACT OF KISSPEPTIN AND BRAIN NEUROTROPHIC FACTOR

PREMATURE OVARIAN FAILURE DUE TO COVID-19: IMPACT OF KISSPEPTIN AND BRAIN NEUROTROPHIC FACTOR

Bakoeva N.M. Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y.Kh. Turakulov

Resume

Premature ovarian failure (POF) is the cessation of ovarian function before the age of 40 years. Being the main cause of infertility and a decrease in the quality of life of women, POF is one of the most difficult problems of female reproduction. After a confirmed diagnosis, there are currently no methods to restore ovarian function and fertility. Therefore, it is important to identify risk factors for the development of POI at an earlier stage. The aim of the study is to identify hypothalamic markers such as kisspeptin (KISS1) and brain-derived neurotrophic factor (BDNF) in the development of premature failure in post-COVID-19 women. Materials and methods. Clinical and laboratory examination data of 112 women: 52 women with POI that developed after COVID-19, 28 women with established POI without COVID-19, 32 women of childbearing age with a regular menstrual cycle. Results. The most pronounced decrease in the concentration of kisspeptin (less than 298.1 pg/ml) was observed in patients with POI after suffering COVID-19, and higher levels of kisspeptin (more than 401.16 pg/ml) were found in healthy women. Of interest was the fact that in women with POI in the comparison group, the level of kisspeptin (ranging from 310 to 387.1 pg/ml) was somewhat lower than in healthy women. The average blood BDNF was significantly lower in women of the main group (231.82±7.3 pg/ml) compared to the control group (428.59±7.22 pg/ml). In women with POI in the comparison group, the level of brain-derived neurotrophic factor was lower (336.15±7.12 pg/ml) than in healthy women. Based on this, we can conclude that the level of BDNF in women with premature ovarian failure is lower than in healthy women, in the case of a coronavirus infection, its level decreases even more. Conclusions. Kisspeptin can be considered as a promising neuropeptide for regulating the female reproductive system and correcting reproductive disorders. Brain-derived neurotrophic factor should be considered as a marker of depression.

Keywords: premature ovarian failure, kisspeptin, BDNF, COVID-19.

First page

70

Last page

76

For citation: Bakoeva N.M. – PREMATURE OVARIAN FAILURE DUE TO COVID-19: IMPACT OF KISSPEPTIN AND BRAIN NEUROTROPHIC FACTOR //New Day in Medicine 2023 7(57): 70-76 https://newdaymedicine.com/index.php/2023/07/17/l-257/

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